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吡唑并三嗪[1,5-a][1,3,5]-4(3H)-酮类衍生物的合成 被引量：1

Synthesis of Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one Derivatives
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摘要 设计并实现了以具有脒代吡唑结构的中间体与三聚光气在低温下进行分子内环合得到吡唑并三嗪[1,5-a][1,3,5]-4(3H)-酮衍生物(9a^9c)的新方法。1H NMR,IR,MS和元素分析表征证明9a^9c为新化合物。 A novel method of preparing pyrazolo [ 1,5-a] [ 1,3,5 ] triazin-4 （3H） -one derivatives （9a -9c） has been developed by eyelization of amidine pyrazol intermediates with triphosgene at low temperature. 9a - 9c are new compounds characterized by 1^H NMR, IR, MS and elemental analysis.
作者 苏熠东 郑云红 李援朝
机构地区 中国科学院上海生命科学院上海药物研究所新药研究国家重点实验室
出处 《合成化学》 CAS CSCD 2006年第4期380-383,401,共5页 Chinese Journal of Synthetic Chemistry
关键词 杂环 芳酮 三聚光气 关环 heteroeyele atone triphosgene eyelization
分类号 O626.25 [理学—有机化学]
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参考文献7

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同被引文献38

  • 1李冶,刘亚婧,袁孝烨,宫平.5,7-二取代吡唑并[1,5-a]嘧啶类化合物的合成及其抗肿瘤活性[J].中国药物化学杂志,2007,17(1):18-22. 被引量：7
  • 2罗义芬,葛忠学,王伯周,张海昊,刘愆.二硝基吡唑并吡唑(DNPP)合成工艺研究[J].含能材料,2007,15(3):205-208. 被引量：13
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  • 7Holla B S, Mahalinga M, Karthikeyan M S. Synthesis of some novel pyrazolo [3,4-d] pyrimidine derivatives as potential antimicrobial agents[J]. Bioorg Med Chem, 2006, 14: 2040-2047.
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合成化学
2006年 第4期

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