脂肪栓塞综合征的病因和发病机制的研究及其进展

Progress in the Etiopathogenisis and Pathogenesy of Fat Embolism Syndrome

脂肪栓塞综合征导致的组织损伤,既可以是脂肪颗粒阻塞血管导致的直接损伤,以及游离脂肪酸毒性的破坏所引起,又可以是激活的血小板、凝结物和纤维蛋白级联反应的结果。近年来的临床和实验研究表明,脂肪栓塞综合征的发生亦与人体肺内血管紧张素转换酶的活性和全身炎性反应综合征有关。

Fat embolism syndrome can produce tissue damage by direct injury as a result of vascular occlusion by fat embolus and the destroy from toxicity of free-fatty acids,as well as the result of cascade reaction resulting from activated platelet, coagulation and fibrin. Recently, clinical and experimental studies suggest that the development of this syndrome has been associated with both angiotensin-converting enzyme activity and systemic inflammatory response syndrome.