中药联合RF及TACE对原发性肝癌患者免疫功能的影响

Effect of Chinese Herb Combining with Radio-frequence and Transcatheter Hepatic Arterial Chemoembolization on Immune Function of the Patients with Hepatocellular Carcinoma

目的:观察中药联合RF及TACE对原发性肝癌患者免疫功能的影响。方法:采用历史对照法,34例患者分为A组(中药组)、B组(TACE组)、C组(RF+TACE+中药组)、D组(RF组)比较各组治疗前后淋巴细胞转换率、T细胞亚群的变化。结果:同治疗前相比,B、D两组淋巴细胞转换率、CD4+、CD8+均明显下降(P<0.05),A、C两组淋巴细胞转换率无明显变化,CD4+、CD8+有所提高,但无统计学差异(P>0.05)。结论:RF、TA-CE治疗可引起HCC患者免疫功能的下降,中药可有效保护TACE及RF治疗引起的HCC患者免疫功能的下降。

Objective： To investigate the effect of Chinese herb combining with radio - frequence （RF） and transatheter hepatic arterial chemoembolization （TACE） on immune function of the patients with hepatocellular carcinoma （HCC）. Methods： History contrast method was used in this study. Thirty four patients with HCC were divided into Chinese herb group （ group A）, TACE group （ group B）, RF, TACE and Chinese herb group （ group C）, RF group （ group D）. Lymphocyte transformation rate and T cell subset of before and after treatment were analyzed. Results ： Compared with the before treatment, the lymphocyte transformation rate, CD4^＋ and CD8^＋ cell counts of group B and D were markedly decreased （ P 〈0. 05）. In group A and C, the lymphocyte transformation rate was unchanged, while CD4^＋ and CD8^＋ cell counts were increased （P 〉 0.05）. Conclusion RF and TACE can cause the reduction in immune function of patients with HCC, which can be effectively protect by Chinese herb treatment.