芪参降脂饮对实验性动脉粥样硬化大鼠的血管内皮功能及胰岛素敏感性的影响

Effects of Qishenjiangzhiyin on insulin sensitivity and vascular endotheial function with experimental atherosclerosis rats

目的探讨芪参降脂饮对实验性动脉粥样硬化(AS)大鼠的血管内皮功能及胰岛素敏感性(IS)的影响。方法24只大鼠随机分为正常对照组、高脂对照组、芪参降脂饮组,每组各8只,分别予以普通饲料和高脂饲料,芪参降脂饮组同时灌服芪参降脂饮。6 wk后分别测血脂谱、血FPG、FINS、ET、6-k-PGF1a、TXB2并计算ISI、TXB2/6-k-PGF1a。结果芪参降脂饮组大鼠TC、LDL-C、ET、TXB2、TXB2/6-k-PGF1a、FPG、FINS显著低于高脂对照组,而HDL-C、6-k-PGF1aI、SI明显升高(P<0.01)。结论芪参降脂饮可以改善血管内皮功能及增强IS进而起到抗AS的作用。

AIM To study the effects of Qishenjiangzhiyin（QSJZY） on vascular endotheial function and insulin sensitivity（IS） with experimental atherosclerosis（AS）rats induced by high fat diet. METHODS Twenty-four rats were randomized into 3 groups. One group served as normal control group, the second group was fed with high-fat diet and served as atherosclerosis model group. The third group was fed with high-fat diet in junction with QSJZY. Serum lipids, FPG, FINS, ET, 6-k-PGF1a, TXB2 were measured and ISI and TXB2/6-k-PGF1a were calculated after 6 wk after experiment. RESULTS In treatment group, TC, LDL-C, ET, TXB2, TXB2/6-k-PGF1a, FPG and FINS were significantly lower and HDL-C,6-k-PGF1a and ISI were significantly higher than those in high-fat group（ P 〈 0.01 ）. CONCLUSION QSJZY can improve vascular endotheial function and can enhance IS, which might be the mechanisms of QSJZY＇s antiatherosclerosis action.