大剂量γ-氨基丁酸和二巯基丙磺酸钠对急性毒鼠强中毒小鼠的实验治疗对比研究

Therapeutic effects of high dose γ-aminobutyric acid contrast with Sodium dimercaptopropane sulfonate on acute tetramine poisoning in mice

目的观察大剂量γ-氨基丁酸(GABA)对急性毒鼠强(TET)中毒小鼠的治疗作用,并与二巯基丙磺酸钠(Na-DMPS)解毒效果相比较,为其临床应用提供实验基础。方法通过小鼠急性毒性实验观察染毒即刻以及染毒10 min后分别给予大剂量GABA和二巯基丙磺酸钠的解毒作用。同时观察各组小鼠脑组织细胞病理学改变。结果高剂量GABA与Na-DMPS治疗急性毒鼠强中毒小鼠,二者均能有效缓解急性毒鼠强中毒小鼠症状、降低中毒小鼠的病死率,中毒后即刻用药治疗比10 min后用药治疗效果较好。另外,Na-DMPS即刻治疗组在延长急性中毒小鼠强直发作潜伏期方面的治疗效果要优于大剂量GABA。结论大剂量GABA对急性毒鼠强中毒小鼠有明显治疗作用,但在GABA对毒鼠强解毒的具体的量效关系方面尚需进一步探讨。

Objective It is purposed to compare the antidotal effects of high dose γ- aminobutyric acid （GABA） on acute tetramine poisoned mice to that of Sodium （Na- DMPS） in order to study the therapeutic effects of GABA further, Method Through the acute toxicity experiment, the antidotal effects of GABA or Na - DMPS on posoned mice were odserved individually. And all brain tissue slices of poisoned mice were made to study the changes of cell pathology. The survival analysis was used to analyze observation data. Results Both GABA and Na - DMPS could obviously prolong poisoned mice survival time, delay poisoned mice onset of convuision and muscular twitch, and improve poisoned mice symptoms after acute tetramine poisoning, Better effects could be achieved with earher use of GABA or Na- DMPS. There was no significant difference between GABA and Na- DMPS to be nsed immediately to treat TETS poisoned mice in prolonging the survival time. Conclusion High dose GABA could effectively antagonize aeute ioxicity of teramine in mice .But its indications and Correct dose in clinical use should be studied further.