红花黄色素对衰老模型小鼠脑细胞凋亡的影响

An experimental study of safflower yellow pigment on cerebrocellular apoptosis in senile model mice

目的:探讨红花黄色素对衰老模型小鼠脑细胞凋亡及其相关因素的影响及其作用机制。方法:采用D—半乳糖制作衰老模型小鼠作研究对象,用大孔树脂法提取红花黄色素,同时观察不同剂量红花黄色素对脑细胞凋亡及Bcl—2的影响作用。结果:红花黄色素能显著降低脑细胞凋亡率,提高Bcl—2的表达,以大剂量和中剂量组效果比较显著(P<0.01,P<0.05)。结论:红花黄色素是红花延缓衰老作用的有效成分,衰老导致脑细胞凋亡大量出现,红花黄色素减少脑细胞凋亡率,以红花黄色素大剂量组效果最佳。

Objective：To investigate the effect of safflower yellow pigment on cerebrocellular apoptosis and correlate factor in senile model mice. Method： We established senile model mice with D-galactose. The safflower yellow pigment was extracted by means of big aperture resin. The effects of various dosage of safflower yellow pigment on cerebro cellalar apoptosis and Bcl-2 were observed. Result：Safflower yellow pigment could obviously decrease cerebrocellular apoptosis and enhanced the levels of Bcl-2. Conclusion： Safflower yellow pigment is an active component of carthamin tinctorius in delayed senescence, it can inhibit apoptosis starting and obviously decrease cerebrocellular apoptosis.