复方中药对主动吸烟动物抗炎与镇咳作用的研究

The study on anti-inflammatory and cough-inhibitory action of compound traditional Chinese herb in the active smoking model of animals

目的 观察复方中药对动物主动吸烟的抗炎与镇咳作用。 方法 分别采用二甲苯耳廓肿胀法、浓氨水引咳法，比较小鼠主动吸入迎客松贵宾香烟与药物香烟15d后对所致炎症的影响与镇咳作用。 结果 与正常对照组相比，药物香烟高剂量组能明显减轻二甲苯所致的耳廓肿胀（P＜0．05）；高、中剂量组2 min内小鼠咳嗽次数明显减少（P＜0．01），咳嗽潜伏期明显延长（P＜0．01，P＜0．05）；与迎客松香烟相比，药物香烟高剂量组2 min内小鼠咳嗽次数明显减少（P＜0．05），咳嗽潜伏期明显延长（P＜0．05）。 结论 高剂量药物香烟有一定的抗炎作用与镇咳作用，且呈剂量依赖性。

Aim To study the anti-inflammatory and coughinhibitory action of compound traditional Chinese herb （CTCH） on the active-smoking model of animals. Methods The models of ear swelling caused by dimethylbenzene and cough induced by dense ammonia water were used to compare the effect of Ying Ke Song （ YKS ） cigarettes and drug cigarettes on anti-inflammatory and cough-inhibitory action in the active smoking model of mice for 15 days. Results Compared with control group, drug cigarettes with high dosage markedly alleviated the ear swelling caused by dimethylbenzene and number of cough times within 2 minutes in the high and medium dosages groups was obviously reduced （ p 〈 0. 01 ） while cough latency was drastically lengthened （p 〈0.01, p 〈0.05） Compared with YKS cigarettes group, number of cough times within 2 minutes was apparently reduced （p 〈 0. 05 ） in the high dosages drug cigarettes groups,meanwhile, cough latency was distinctly lengthened （p 〈 0. 05）. Conclusion High dosages drug cigarettes had anti-inflammatory and cough-inhibitory action, and was dosedependent.