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正常成年大鼠脑内环氧合酶-2的表达

Expression of cyclooxygenase-2 in the brains of normal adult rats
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摘要 目的:观察正常大鼠脑内环氧合酶-2(COX-2)的表达.方法:用自行制备的COX-2多抗采用免疫组织化学ABC法观察了COX-2蛋白在正常成年大鼠脑内的表达.结果:在正常成年大鼠脑内COX-2蛋白主要表达于皮层、海马、齿状回、视上核、杏仁核、小脑和脑干等部位,阳性细胞主要为神经元,神经胶质细胞染色很少.结论:COX-2蛋白在脑内广泛分布. AIM： To observe the expression of cyclooxygenase-2 （COX-2） in the brains of normal adult rats. METHODS： The immunohistochemical ABC method and the COX-2 polyclonal antibody which was produced by ourselves were used to observe the expression of COX-2 protein in the brains of normal adult rats. RESULTS： There was plentiful COX-2 protein in the cortex, the hippocampus, the dentate gyrus, the supraoptic nucleus, the amygdaloid nucleus, cerebellum and brain stem, and so on. The COX-2 immunopositive cells were mainly neurons, and a few were glial cells. CONCLUSION： COX-2 protein is distributed widely in the brain.
作者 汪丙昂 赵振伟 孟新文
机构地区 解放军第三医院骨科 第四军医大学唐都医院神经外科
出处 《第四军医大学学报》 北大核心 2006年第13期1176-1177,共2页 Journal of the Fourth Military Medical University
关键词 环氧合酶-2 大鼠 免疫细胞化学 cyclooxygenase-2 rat immunocytochemistry
分类号 R392 [医药卫生—免疫学]
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参考文献5

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二级参考文献26

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共引文献12

第四军医大学学报
2006年 第13期

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