卵巢原发非霍奇金淋巴瘤的临床病理分析

A Clinicopathologic Analysis of Primary Ovarian Non-Hodgkin's Lymphoma

目的观察卵巢原发非霍奇金淋巴瘤的临床病理表现,探讨该类肿瘤的临床病理特征及病理诊断。方法对15例卵巢原发非霍奇金淋巴瘤作临床病理观察及随访,按WHO关于淋巴造血组织肿瘤分类(2001)进行组织学分型和诊断。采用SP法进行免疫表型检测。结果该类肿瘤占同期收治的非霍奇金淋巴瘤的0.56%(15/2679),其中,临床Ⅲ期或Ⅳ期者有12例(80%),临床Ⅰ期或Ⅱ期者3例(20%)。组织学分型:15例(100%)均为弥漫大B细胞淋巴瘤,中心母细胞性或免疫母细胞性。所有病例均接受了手术治疗,3例术后分别用CHOP或COM P方案治疗。4例有随访资料者均死亡,生存时间为21 d^18月。结论卵巢原发非霍奇金淋巴瘤少见,预后差。肿瘤的确诊依赖病理学检查和免疫表型检测。

Objective To observe the clinicopathologic manifestations and to investigate the clinicopathologic features and diagnosis of primary ovarian non-Hodgkin＇s lymphoma. Methods A retrospective study of clinicopathology was made for 15 cases of primary ovarian non-Hodgkin＇s lymphomas. The histological classifying was based on the WHO classification for tumors of hematopoietie and lymphoid tissues （2001）. Immunophenotype analysis was made by SP method. Results This kind of tumor was accounted for 0.56% of all non-Hodgkin＇s lymphoma （NHL） received in the same period. In all 15 cases, the patients of stage Ⅲ and Ⅳ were 12（80%）, and stage Ⅰ and Ⅱ were 3 cases （20%）. Histological classification： all 15 cases （100%） were diffuse large B cell lymphoma （DLBCL）, centroblast or immunoblast types. All patients had received operation; three of them also received chemotherapy of CHOP or COMP. The follow-up data was available for 4 cases, and all of them died within period of 21 days to 18 months. Conclusion Primary ovarian non-Hodgkin＇s lymphoma is rare and the prognosis is usually poor. Establishment of the diagnosis is based on pathological biopsy and immunophenotype analysis. Owing to the diagnosis made usually after most cases operated, the surgical treatment is still the essential, and the chemotherapy and radiotherapy are also adjuvant for the tumor.