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阿尔茨海默病中α分泌酶的研究进展 被引量：3

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作者 魏翠柏 贾建平
机构地区 首都医科大学北京宣武医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2006年第6期421-423,共3页 Chinese Journal of Neurology
基金 中国博士后科学基金资助项目(2005037382)
关键词 阿尔茨海默病 分泌酶 神经系统退行性疾病 disease 淀粉样前体蛋白 protein 临床应用价值 代谢紊乱 代谢途径 活化途径
分类号 R749.1 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献19

  • 1Colciaghi F,Marcello E,Borroni B,et al.Platelet APP,ADAM 10 and BACE alterations in the early stages of Alzheimer disease.Neurology,2004,62:498-501.
  • 2Stein TD,Anders NJ,DeCarli C,et al.Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons:support for the amyloid hypothesis.J Neurosci,2004,4:7707-7717.
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  • 4Asai M,Hattori C,Szabo B,et al.Putative function of ADAM9,ADAM10,and ADAM17 as APP alpha-secretase.Biochem Biophys Res Commun,2003,301:231-235.
  • 5Kojro E,Fahrenholz F.The non-amyloidogenic pathway:structure and function of alpha-secretases.Subcell Biochem,2005,38:105-127.
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  • 8Hartmann D,de Strooper B,Serneels L,et al.The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.Hum Mol Genet,2002,11:2615-2624.
  • 9Hotoda N,Koike H,Sasagawa N,et al.A secreted form of human ADAM9 has an alpha-secretase activity for APP.Biochem Biophys Res Commun,2002,293:800-805.
  • 10Fahrenholz F,Gilbert S,Kojro E,et al.Alpha-secretase activity of the disintegrin metalloprotease ADAM 10.Influences of domain structure.Ann N Y Acad Sci,2000,920:215-222.

二级参考文献17

  • 1Querfurth HW, Jiang J, Geiger JD, et al. Caffeine stimulates amyloid beta - peptide release from beta - amyloid precursor protein - transfected HEK293 cells. J Neurochem, 1997, 69(4) : 1580- 1591.
  • 2Nitsch RM, Deng M, Growdon JH, et al. Serotonin 5 - HT2a and 5 -HT2c receptors stimulate amyloid precursor protein ectodomain secretion. J Biol Chem, 1996, 271(8):4188-4194.
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  • 4Yogev - Falach M, Amit T, Bar - Am O, et al. Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline. FASEB J, 2002, 16(12): 1674- 1676.
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  • 6Mudher A, Chapman S, Richardson J, et al. Dishevelled regulates the metabolism of amylold precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J Neursci, 2001,21 (14) : 4987 - 4995.
  • 7Yamatsuji T, Okamoto T, Takeda S, et al. Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait - linked phenotype.EMBO J, 1996, 15(3) : 498 - 509.
  • 8Mbebi C, See V, Mercken L, et al. Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase Ⅳ- dependent signaling pathway. J Biol Chem, 2002, 277(23) : 20979 - 20990.
  • 9Cheng G, Yu Z, Zhou D, et al. Phosphatidylinositol - 3 - kinase - Akt kinase and p42/p44 mitogen - activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein. Exp Ncurol, 2002, 175(2) : 407 - 414.
  • 10Luo Y, Sunderland T, Wolozin B. Physiologic levels of beta - amyloid activate phosphatidylinositol 3 - kinase with the involvement of tyrosine phosphorylation. J Neurochem, 1996, 67(3) : 978 - 987.

共引文献2

同被引文献41

  • 1魏翠柏,田金洲,贾建平.老年痴呆中医病因病机理论的认识与思考[J].中华中医药杂志,2005,20(8):496-498. 被引量：82
  • 2Wolfe MS.gamma-Secretase in biology and medicine.Semin Cell Dev Biol,2009,20:219-224.
  • 3Selkoe DJ,Wolfe MS.Presenilin:running with scissors in the membrane.Cell,2007,131:215-221.
  • 4De Strooper B.Aph-1,Pen-2,and Nicastrin with Presenilin generate an active gamma-Secretase complex.Neuron,2003,38:9-12.
  • 5Spasic D,Annaert W.Building gamma-secretase:the bits and pieces.J Cell Sci,2008,121 Pt4:413-420.
  • 6Kimberly WT,LaVoie MJ,Ostaszewski BL,et al.Gammasecretase is a membrane protein complex comprised of presenilin,nicastrin,Aph-1,and Pen-2.Proc Natl Acad Sci U S A,2003,100:6382-6387.
  • 7Steiner H,Winkler E,Haass C.Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.J Biol Chem,2008,283:34677-34686.
  • 8Francis R,McGrath G,Zhang J,et al.aph-1 and pen-2 are required for Notch pathway signaling,gamma-secretase cleavage of betaAPP,and presenilin protein accumulation.Dev Cell,2002,3:85-97.
  • 9Shirotani K,Edbauer D,Prokop S,et al.Identification of distinct gamma-secretase complexes with different APH-1 variants.J Biol Chem,2004,279:41340-41345.
  • 10Ma G,Li T,Price DL,et al.APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.J Neurosci,2005,25:192-198.

引证文献3

二级引证文献9

中华神经科杂志
2006年 第6期

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