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低密度脂蛋白受体功能及其影响因素研究进展 被引量：13

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摘要 低密度脂蛋白受体是一种细胞表面糖蛋白,主要功能是结合低密度脂蛋白或其它含载脂蛋白B100及载脂蛋白E的脂蛋白,然后内吞入细胞,在胆固醇代谢中起关键作用,但其功能受遗传、内分泌等多种因素的综合影响;同时,各种遗传和环境因素也可从转录、转录后等不同水平调节低密度脂蛋白受体的表达。研究证实,提高和促进低密度脂蛋白受体基因表达,可使血中低密度脂蛋白水平降低;反之,则低密度脂蛋白水平升高。本文提出应积极在低密度脂蛋白受体基因表达与调控水平提高其功能,预防高胆固醇血症和动脉粥样硬化的发生。
作者 陈芬 王绿娅 尹卫东
机构地区 南华大学心血管病研究所 北京市心肺血管疾病研究所动脉粥样硬化研究室
出处 《中国动脉硬化杂志》 CAS CSCD 2006年第5期448-450,共3页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金(30470722) 北京市自然科学基金(7032012和7052021) 北京市科技新星项目(04B27)联合资助
关键词 病理学与病理生理学 低密度脂蛋白受体 综述 受体功能 影响因素
分类号 R363 [医药卫生—病理学]
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参考文献22

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二级参考文献40

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共引文献13

同被引文献146

引证文献13

二级引证文献85

中国动脉硬化杂志
2006年 第5期

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