雄激素受体和雌激素受体在喉癌中的表达

Expression of androgen receptor and estrogen receptor in carcinoma of larynx

目的:探讨雄激素受体(AR)和雌激素受体(ER)在喉癌发生、发展中的作用。方法:应用原位杂交法对63例喉癌组织、20例癌旁正常组织和20例喉良性病变组织进行AR和ER的测定。结果:AR和ER在癌旁正常组织和喉良性病变组织中的表达均为阴性;在喉癌组织中AR的阳性表达率为68.3%,ER为69.8%,AR和`ER在喉癌组织中的表达与患者性别、临床分型无关(均P>0.05)。AR的表达率随喉癌的病理分级和临床分期的升高而增高,ER则相反(P<0.01或P<0.05)。有淋巴结转移者AR表达增强,ER表达降低,分别与无淋巴结转移者比较,差异均有统计学意义(P<0.05或P<0.01)。结论:性激素受体的表达与喉癌的发病有关,AR和ER可作为了解肿瘤的恶性程度和预后的标志;但AR及ER的表达与患者性别无关,因此,尚不能用AR及ER的表达来解释喉癌发病率在性别上的差异,说明男女喉癌在发病率上的明显差异可能还有其他因素参与。

Objective：To study the expressions of androgen receptor （AR）and estrogen receptor （ER） in the pathogenesis of laryngeal carcinoma. Method：The method of in situ hybridization was employed to detect the expressions of AR and ER in 63 specimens of laryngeal carcinoma, 20 specimens of normal tissue beside carcinoma and 20 specimens of laryngeal benign lesion. Result：The expressions of AR and ER in specimens of normal tissue and laryngeal benign lesion were negative. The expressions of AR in laryngeal carcinomas was 68.3 %, the expressions of ER was 69.8% ,which was not correlated with sex and clinical classification（ P〈0.05）. With the differentiation of pathologic-classify and clinical stage, the expressions of AR in carcinoma of larynx were significantly increased,but ER was opposite（ P 〈0.05）. The expression of AR was observed more frequently in patients with lymph node metastasis,but the expression of ER was degraded（ P 〈0.05）. Compared with carcinoma of larynx, the expressions of AR and ER in specimens of normal tissue laryngeal benign lesion were significantly different （ P〈0.01）. Conclusion：The expressions of sex hormone acceptor are concerned with the incidence of carcinoma of larynx. The expressions of AR and ER are closely related to pathologic-classify , clinical stage and lymph node metastasis..AR promoted the growth of larygeal carcinoma,but ER restrained it. AR and ER could be marked to understand malignant degree and prognosis, but they were not correlated with sex and clinical classification. The difference in expression of AR and ER does not explain the difference of sex and incidence of laryngeal carcinoma difference in expression of AR and ER,it shows that the significant difference of sex in the incidence of carcinoma of larynx may be concerned with other factors.