胆囊收缩素在糖尿病并发胆囊结石中的地位与作用

Effects of Cholecystokinin on Diabetes Mellitus Complicated with Cholecystolithiasis

目的探讨胆囊收缩素(CCK)在糖尿病并发胆囊结石中的地位与作用。方法复习近几年的相关文献并进行综述。结果CCK在体内分布广泛,一方面通过引起糖尿病而促进胆囊结石的发生,另一方面其本身及其受体异常也可以引起胆囊结石,与CCK有关的基因异常可能是糖尿病和胆囊结石共同的病理基础。结论CCK在糖尿病并发胆囊结石的发病中具有重要作用,但仍需进行深入研究。

Objective To investigate the effects of cholecystokinin （CCK） on diabetes mellitus with cholecystolithiasis. Methods Relevant literatures of recent years were reviewed. Results CCK exists widely in human body. On the one hand, CCK enhances cholecystolithiasis by causing diabetes. On the other hand, its pathological changes can also lead to cholecystolithiasis. Besides, it is possibility that the CCK-related gene abnormality is the common cause of diabetes and cholecystolithiasis. Conclusion CCK plays an important role in diabetes mellitus complicated with cholecystolithiasis. However, there is much yet to be known about CCK.