趋化性细胞因子ENA-78对子宫内膜异位症的作用

The role of chemokines ENA-78 in endometriosis

子宫内膜异位症(EM)是常见的妇科疾病,表现为子宫内膜出现在子宫腔外,并具有生长和侵袭的能力。关于其发病机制,尽管提出了很多假说,但其确切的发病机制仍不十分清楚。最近的研究显示,腹腔液中的很多因子在异位子宫内膜的种植、侵袭、新血管生成及增殖中起重要作用,趋化性细胞因子ENA-78对子宫内膜异位症的发生、发展有重要意义。

Endometriosis is a common gynecologic disorder defined by the presence, growth, and invasion of endometrial tissue outside the uterine cavity. Although many hypotheses have been proposed, the etiology of the disease remains an enigma. Recent studies have suggested that factors within the peritoneal fluid contribute to endometriotic implant invasion, neovascularization, and proliferation. Chemokines, especially ENA-78, similar to IL-8, are postulated to play an essential role in the local inflammatory reactions seen in endometriosis.