侵袭性垂体腺瘤中CD44与Ki-67表达的相关性

Expression and Relationship between CD44 and Ki-67 in Invasive Pituitary Adenoma

目的探讨细胞粘附分子CD44、细胞增值核抗原Ki-67在侵袭性垂体腺瘤中的表达及意义并探讨二者之间的关系。方法用免疫组化法检测CD44s、CD44v5、Ki-67在20例侵袭性垂体腺瘤和18例非侵袭性垂体腺瘤中的表达。结果CD44s和Ki-67在侵袭性垂体腺瘤组中表达高于非侵袭性垂体腺瘤组(P<0.01),且二者在垂体腺瘤中的表达呈正相关。CD44v5在侵袭性和非侵袭性垂体腺瘤中表达无明显差异(P>0.05)。结论CD44s和Ki-67与垂体腺瘤的侵袭性生长行为有关,二者协同作用,在侵袭性垂体腺瘤的发生、发展中起重要作用,可作为侵袭性垂体腺瘤诊断和判断预后的重要生物学指标。

Objective To study the expression and role of CD44 and Ki-67 in invasive pituitary adenoma and the relationship between them. Methods The expression of CD44s,CD44v5 and Ki-67 in 20 cases invasive pituitary adenoma and 18 cases non-invasive pituitary adenoma were detected with SP immunohistochemical technique. Results The expressive levels of CD44s and Ki-67 in the invasive pituitary adenomas were significantly higher than those in the non-invasive ones （P〈0. 01 ）, it is positively correlation between them. The expression levels of CD44v5 in the invasive and non-invasive pituitary adenomas has no difference. Conclusion CD44s and Ki-67 correlated with invasiveness of pituitary adenoma, they cooperated and play a important role in occurrence and progression of pituitary adenoma. They may be an objective biological marker for diagnose and estimating prognosis of invasive pituitary adenoma.