白细胞介素-8的表达与乳腺癌预后的关系

The relationship between expression of interleukin-8 and prognosis of breast cancer

目的探讨白细胞介素-8(IL-8)在乳腺癌组织中的表达及与预后的关系。方法应用组织芯片技术,通过免疫组化法,检测IL-8在113例乳腺癌、19例乳腺良性肿瘤和20例正常乳腺组织中的表达,分析其与乳腺癌临床病理特征及预后的关系。结果IL-8在乳腺癌组织中的阳性表达率为27．4％,明显高于在乳腺良性肿瘤(5．3％)及正常乳腺组织(0)中的表达(X2=9．936,P= 0．002)。IL-8表达与乳腺癌组织学类型(X2=4．202,P=0．040)和淋巴结转移(X2=7．716,P= 0．021)有关;IL-8阳性率与ER、PR表达呈负相关(X2=5．885,P=0．015和X2=4．504,P=0．034),与C-erbB-2表达呈正相关(X2=9．276,P=0．002)。IL-8表达阳性组与阴性组的5年无瘤生存率分别为63．89％和87．08％,差异有统计学意义(QPH=4．67,P=0．031)。结论IL-8阳性表达提示乳腺癌预后不良。IL-8可作为评价乳腺癌预后的新的生物学指标,为乳腺癌综合治疗提供依据。

Objective To investigate the expression of intedeukin-8 （IL-8） and its prognostic signifcance in breast cancer. Methods Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient＇s clinico-pathological characteristics and prognosis was further analyzed. Results The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast （ P = 0. 002 ）. IL-8 expression related to histological type （ P = 0. 040 ） and lymph node status （ P = 0. 021 ）. The expression of IL-8 was observed to correlate negatively with ER and PR status （P = 0. O15 and P = 0. 034） , and correlate positively with C-erbB-2 status （P = 0. 002 ）. In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group （ P = 0. 031 ）. Conclusions IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.