阿尔茨海默病免疫治疗的前景

Research and Development on Immunotherapy of Alzheimer's Disease

阿尔茨海默病(A lzhe im er’s d isease,AD)是最常见的痴呆性疾病,严重影响患者的工作能力及生活质量,也为家庭和社会带来沉重的负担。迄今为止,AD一直缺乏有效的治疗方法。免疫治疗为AD患者带来了希望,主动免疫治疗虽在动物模型上取得良好效果,但在少数AD患者中诱发产生了脑膜脑炎。被动免疫治疗在动物模型和AD患者中的效果较另人满意,但仍需继续观察是否存在不良反应。

Alzheimer＇ s disease （AD）, the most common form of dementia, it is lack of effective cure or preventive treatment. Dementias in the elder are an increasing medical, social and economic problems and current treatments are only mildly effective. Recently, amyloid-beta protein （Aβ） has become a major therapeutic target. Aβ vaccine treatment can improve cognition in the patients with AD, but adverse events, such as meningencephalitis were observed in clinical study. The passive Aβ immunotherapy in humans is effective with possible safety. However, patients need to be monitored carefully.