神经末梢突触囊泡相关的调节蛋白

Regulating Proteins Participating in Neurotransmitter Release of Synaptic Vesicles at Nerve Terminals

神经末梢突触囊泡释放神经递质是一个受到精细调控的过程,涉及多种蛋白质间的网络状相互作用,包括蛋白复合物的组装和构象调节、突触囊泡的定向性运输、囊泡入坞、膜融合、递质释放以及囊泡膜和蛋白的重摄取等,这一大循环里的每一步都离不开各种相关蛋白的相互作用。该文围绕这些调控蛋白的分子结构、生理功能以及蛋白间的相互作用作一综述。

Neurotransmitter release is controlled by groups of proteins associated with the membranes of synaptic vesicles and the presynaptic membranes. It is a highly dynamic process which is spatially and temporally regulated via a cascade of protein-protein interactions. These proteins participate in each step of the synaptic vesicle circulation at nerve terminals including the formation of soluble N-ethylmaleimide-sensitive factor-attachment protein receptors complex, the targeted trafficking of synaptic vesicles, the vesicle docking, the neurotransmitter release and finally the reuse of the proteins. This article focuses on the physiological function and the interactions of these regulating proteins.