长期木兰拳运动对中老年女性自由基代谢和NO的影响

The effects of long-term Mulanquan exercise on free radical metabolism and nitric oxide in middle aged and elderly women

目的观察长期规律木兰拳运动对中老年女性自由基代谢和一氧化氮的影响。方法自愿参加本次测试的50～60岁女性49人,其中长期坚持规律木兰拳练习2年以上者27人为实验组；无运动习惯,平时极少参加体育锻炼者22人为对照组。对血清丙二醛(MDA)含量、血清超氧化物歧化酶(SOD)活性、血清谷胱甘肽过氧化物酶(GSH-Px)活性、血清过氧化氢酶(CAT)活性、血清一氧化氮(NO)含量进行定量测定。结果①实验组血清MDA含量低于对照组,差异有统计学意义(P＜0．01)；实验组血清SOD活性、GSH- Px活性高于对照组,差异有统计学意义(P＜0．01)；两组血清CAT活性差异无统计学意义；实验组血清NO含量高于对照组,差异有统计学意义(P＜0．05)。②血清NO含量与血清SOD活性、GSH-Px活性、SOD/MDA值正相关,与血清MDA含量负相关。结论长期木兰拳运动能有效抑制中老年女性体内脂质过氧化反应,使自由基抗氧化酶系维持在较高机能水平,从而增加NO的释放,缓解中老年女性内皮依赖的血管舒张功能的减退,有利于血压的调节,对心血管疾病的预防有重要意义。

Objective To observe the effects of long-term Mulanquan exercise on antioxidative capacity and vasodilation. To elucidate the mechanism by which Mulanquan regulates endothelial endocrine function. To provide scientific evidence for Mulanquan＇s regulating blood pressure, improving cardiovascular function and preventing cardiovascular disease. Methods Forty-nine women volunteers were divided into an exercise group and a control group. They were fifty to sixty years old. The exercise group included 27 subjects who had practiced mulanquan regularly for at least two years. The control group comprised 22 subjects who had no habit of exercise. Their levels of serum malondialdehyde （ MDA ） , superoxide dismutase （ SOD ） , glutathione peroxidase （ GSH-Px ） , catalase （ CAT ） and nitric oxide（NO） were quantitatively determined. Results ①Serum MDA was lower in the exercise group than in the control group, and the difference between the two groups was highly significant statistically. Serum SOD activity and GSH-Px activity in the exercise group were higher than in the control group, the differences between the two groups being highly significant statistically. There was no significant difference between the groups in serum CAT activity. The serum NO content of the exercise group was higher than that of the controls, with the inter-group difference statistically significant. ②Serum NO content was positively correlated with SOD activity ,GSH-Px activity,and SOD/MDA, and negatively correlated with MDA content. Conclusion Long-term Mulanquan exercise can suppress lipid peroxidation in middle aged and aged women. It can help maintain high antioxidative capacity, increase the secretion of NO, and thus limit any decrease in endothelium-dependent vasodilatation, which will be good for regulating blood pressure and preventing cardiovascular disease.