米索前列醇在足月妊娠引产中的应用

Application of misoprostol in the induction of labor in patients with term pregnancy

目的:探讨米索前列醇(米索)在足月妊娠引产中的有效性和安全性。方法:米索组92例,于阴道后穹窿置米索25μg引产,抬高臀部平卧半小时后可自由活动,观察宫缩,如无宫缩或出现不规律宫缩后又逐渐减弱或不再增强,可于6小时后再次给药25μg,24小时不超过100μg。催产素组96例,催产素2.5U溶于5%葡萄糖500ml中,从每分钟8滴即2.5mU开始,根据宫缩、胎心情况调整滴速,一般每隔15～30分钟调节1次,直至出现有效宫缩,结果:两组比较,米索组临产发动时间及阴道分娩总产程短,引产成功率高,剖宫产率低,差异有显著性;胎儿窘迫和新生儿窒息率两组之间差异无显著性。结论:米索用于足月妊娠引产优于催产素,是一种有效的引产方法,但其并发症不容忽视。

Objective：To study the effect and safety of misoprostol in the induction of labor in patients with term pregnancy.Methods：92 patients with term pregnancy in the misoprostol group received initially misoprostol 25 μg placed in the posterior fomix of vagina, misoprostol 25 μg was given again after 6 hours until the appearance of the regular uterine contraction.The total dosage was less than 100 μg per day.96 patients in the oxytocin group received oxytocin by intravenous drip as a control group.Results：The average interval from the start of induced labor to onset of labor in the misoprostol group was significantly shorter than that in the oxytocin group（P〈0.05）.When the cervix of primipara was unfavorable for induced labor, the success rate in misoprostol group was higer than that in the oxytoein group （P〈0.05）.But there was no significant difference in the incidence of cesarean section,volume of bleeding and neonatal asphyxia between two groups.Conclusion：It is effective to induce the term pregnancy by repeatedly palcinglow dosage misoprostol in the posterior fornix of vagina,but its complication isn＇t neglected.