特发性肺纤维化急性加重1例并文献复习

Acute exacerbation in idiopathic pulmonary fibrosis(IPF):a case report and review

目的提高对特发性肺纤维化急性加重的认识,并探讨其诊断标准和治疗原则。方法报告并分析中国医科大学附属第一医院呼吸内科2005-11-30收治的1例特发性肺纤维化急性加重的病例,经糖皮质激素大量冲击治疗后好转,并复习国外相关文献。结果通过复习特发性肺纤维化急性加重的临床诊断标准,以强调在没有明确诱因的情况下,少数特发性肺纤维化的患者在自然病程中可出现急性加重,糖皮质激素冲击治疗可缓解部分病人病情。结论少数特发性肺纤维化患者可在自然病程中出现急性加重。

Objective To improve the diagnosis and treatment of acute exacerbation in idiopathic pulmonary fibrosis （IPF） Methods A case with clinical proven acute exacerbation in IPF and treated with corticasteroid was described and the foreign literature was reviewed. Results Most patients with idiopathic pulmonary fibrosis （IPF） show slowly progressive deterioration. However, accelerated deterioration also occurs without any definite factors on infection, heart failure, et al in a few of patients with IPF who have previously shown slowly progressive deterioration, and for part of patients corticosteroid treatment is effective. Conclusion Some acute exacerbation in idiopatic pulmonary fibrosis can be idiopathic.