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α-干扰素治疗慢性乙型肝炎患者肝组织B7-1表达的变化 被引量:2

Expression of B7-1 in liver tissue before and after interferon-alpha treatment in patients with chronic hepatitis B
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摘要 目的了解α-干扰素(-αIFN)治疗慢性乙型肝炎(chronic hepatitis B,CHB)患者前后肝组织B7-1的表达特点。方法采用免疫组织化学方法检测18例正规使用-αIFN的CHB患者治疗前、后肝活检组织共刺激分子(B7-1)的表达及其与-αIFN疗效的关系。结果18例CHB患者肝组织B7-1阳性表达颗粒的平均吸光度值治疗后较治疗前显著增加(分别为24.98±4.23和11.77±2.35,t=11.58,P<0.01)。B7-1表达水平与-αIFN近期疗效呈显著正相关(r=0.68,P<0.01)。结论-αIFN可促进肝细胞B7-1表达,B7-1表达水平可能是预测-αIFN近期疗效的重要参数之一。 Objective To evaluate the expression of B7-1 in liver tissue before and after interferon-alpha treatment (α-IFN) in patients with chronic Hepatitis B (CHB). Methods The expression of B7-1 in liver biopsy specimens from 18 CHB patients was studied with immunohistochmistry before and after α-IFN treatment and the expression was correlated with the response to α-IFN. Results The level of B7-1 expression after α-IFN treatment was found to be increased significantly (average absorbency of positive grain 24.98±4. 23 versus 11.77±2.35,t= 11.58,P〈0. 01 ). There was a positive correlation between B7-1 expression and α-IFN response (r=0. 68,P〈0.01). Conclusion α-IFN may promote B7-1 expression in liver tissue. The level of B7-1 expression may be regarded as an effective parameter for predicting α-IFN response in patients with CHB.
出处 《实用肝脏病杂志》 CAS 2006年第4期201-202,205,共3页 Journal of Practical Hepatology
关键词 慢性乙型肝炎 共刺激分子 Α-干扰素 Hepatitis B B7-1 Interferon-alpha
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  • 1FIORE G, PIAZZOLLA G, GALETTA V, et al. Liver tissue expression of CD80 and CD95 antigens in chronic hepatitis C: relationship with biological and histological disease activities[J]. Microbios. 1999,97(386):29-38.
  • 2SUN J, TUMURBAATAR B, JIA J, et al. Parenchymal expression of CD86/B7.2 contributes to hepatitis C virusrelated liver injury[J]. J Virol. 2005 , 79 (16):10730-10739.
  • 3LEIFELD L, TRAUTWEIN C, DUMOULIN FL, et al.Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure[J]. Am J Pathol. 1999 , 154(6) : 1711-1720.

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