阿苯哒唑对体外培养猪囊虫头节作用的透射电镜观察Ⅰ

OBSERVATIONS OF THE EFFECT OF ALBENDAZOLE ON THE ULTRASTRUCTURES OF EVAGINATED SCOLECEA OF CYSTICERCUS CELLULOSAE CULTURE IN VITRO.I

将已孵化的猪囊虫，分别培养在含不同浓度的阿苯哒唑（５０μｇ／ｍｌ和１００μｇ／ｍｌ）的培养基中７２ｈ和９６ｈ，ＴＥＭ下观察其超微结构的变化。虫体头节皮层变薄或破溃，微毛变短或缺失，肌束扭曲、肿胀并有局灶性溶解，核固体胞浆出现空泡，实质层中出现大量空泡及变性的结构。结果表明，该药在体外条件下，可使孵化猪囊虫超微结构发生病变。

Hatched cysticere of Cysticercus cellulosae were cultivated in the culture medium containing different concentrations (50μg/ml and 100μg/ml ) of albendazole in vitro for 72h and 96h, and the ultrastructural changes of the evaginated seoleces were observed under the transmission electron microscope. The tegument of the scolex became thin and peeling, and microtriches became shorter, fewer in number, or even disappeared . The deformity, swelling and focal lysis were observed in muscle bundles. Vacuolizations appeared in the tegument cells and the parenchyma tissues, and degenerative structure was seen in the parenchyma tissues. The results showed that albendazole can cause pathological changes in the ultrastructures of Cysticercus cellulosae in vitro.