八周太极拳运动对老年人免疫功能的影响

Effect of 8-week Tai Chi Chuan on immune function of older people

目的:观察太极拳运动对健康老年人淋巴系统T和B淋巴细胞免疫功能的影响。方法:①于2004-10选择上海市光三村老年居民20名,男10名,女10名,年龄55～65岁。近期均无从事规律性运动,且对干预方案及检测指标知情同意。按性别1∶1比例将20名老年人分为2组:运动组和对照组,每组10名。②运动组:以杨氏24式太极拳(包括:起势、左右野马分鬃、白鹤亮翅、左右搂膝拗步和手挥琵琶等共24式)为主要内容。每周训练4次,共8周,每次训练60min,包括10min准备活动,40min太极拳运动,10min整理活动,中等强度(50%～65%最大心率)。对照组:不参加任何集体或个人的有计划训练。③训练开始前1d及8周训练结束后第2天用流式细胞分析仪检测T淋巴细胞亚群CD4+和CD8+的百分比表达,计算CD4+与CD8+比值。用Array360system全自动分析仪测定血清免疫球蛋白IgG,IgM和IgA水平。结果:老年人20名均进入结果分析。①实验前2组T淋巴细胞亚群检测结果相近(P>0.05),实验8周后,运动组CD4+表达和CD4+与CD8+比值明显高于实验前[(41.59±4.32)%,1.87±0.28;(32.58±3.16)%,1.07±0.33,t=-4.02,-5.23,P<0.05,0.01],CD8+表达明显低于实验前[(22.25±5.12)%,(30.41±3.57)%,t=3.05,P<0.05]。对照组在实验前后T淋巴细胞亚群检测结果未发生明显变化(P>0.05)。②实验前2组免疫球蛋白水平差异不明显(P>0.05)。实验8周后,运动组IgG和IgA水平明显高于实验前[(12.78±3.30),(3.18±0.96)g/L;(11.20±2.32),(2.56±0.42)g/L,t=-3.72,-2.98,P<0.05];IgM水平也高于实验前,但差异不明显(P>0.05);对照组IgG,IgM和IgA水平低于实验前,但差异不明显(P>0.05)。结论:太极拳训练可有效提高健康老年人T淋巴细胞和B淋巴细胞免疫功能。

AIM： To observe the effect of Tai Chi Chuan （TCC） exercise on T lymphocyte and B lymphocyte immune functions in healthy older individuals. METHODS： ①Twenty older inhabitants from Shignang third country of Shanghai city in October 2004 were selected as subjects. They, aged 55- 56 years and including 10 males and 10 females, were randomly divided into two groups： training group （n=10） and control group （n=10）. These older individuals have known and consented to the testing scheme and have no disciplinarian exercise recently. ②Training group： Exercise contents were mostly twenty-four TCC （Commenting form, Part the Wild Horse＇s Mane on Both Side, White Crane Spreads its Wings, Brush Knee and Twist Step on Both Side and Play Pipa, etc）. Exercise loads were sixty minutes every time and four times every week for eight weeks. Every time exercise comprised ten minutes warming-up, forty minutes TCC exercise and ten minutes relaxation at medium intensity （50%-65% maximal heart rate）. Control group： The patients had no exercise with individual or collective scheme. ③At one day before and after 8-week exercise, the percentages of lymphocyte subpopulations were determined by flow eytometry, then the ratio of CD4^＋/CD8^＋ was calculated. In addition, the serumal immunoglobulin G （IgG）, IgM and IgA were determined by Array 360 system autoanalyzer. RESULTS： Totally 20 older people entered the result analysis. ①The testing results of T lymphocyte subpopulation in two groups had no significant difference before TCC exercise （P 〉 0.05）. After eight-week TCC exercise, the training group showed an increase in the expression of CD4^＋ and significant increase in CD4^＋/CD8^＋ ratio [（41.59±4.32）%, 1.87±0.28; （32.58±3.16）%, 1.07±0.33, t=-4.02, -5.23, P 〈 0.05,0.01], and decrease in the expression of CD8^＋ [（22.25±5.12）%, （30.41±3.57）%, t=3.05, P 〈 0.05]. There was no significant change in the testing results of T lymphocyte subpopulation in control group before and after TCC exercise （P 〉 0.05）. ②The testing results of immunnglobulin in two groups had no significant difference before TCC exercise （P 〉 0.05）. After eight-week TCC exercise, the training group showed increase in the concentrations of IgG and IgA [（12.78±3.30）, （3.18±0.96） g/L; （11.20±2.32）, （2.56±0.42） g/L, t=-3.72, -2.98, P 〈 0.05], and little increase in concentration of IgM, without significant difference （P 〉 0.05）. The control group showed no significant change in these variables, which were still lower than those before exercise （P 〉 0.05）. CONCLUSION： TCC exercise is effective for improving T lymphocyte and B lymphocyte immune functions in healthy older individuals.