白细胞介素-2脂质体的制备及其活性和稳定性的研究

Preparation of IL-2 Liposome and Study on its Stability and Activity

利用逆相蒸发法制备出白细胞介素－2（IL－2）脂质体，其包封率为34．52±1．12％，在电镜下具有典型大单层脂体结构，大小为0．2μm左右。利用“ConA诱导T细胞微量测定法”对其活性进行了测定，结果表明IL－2脂质体，活性提高，稳定性好。

IL-2 liposome was prepared by reverse - phase evaporation method. The envelope rate of it was 34.52±1. 12%. Being observed under electron microscope, the IL-2 liposome showed the typical structure of unilaminar vesicles (LUVs) with an average diameter of 0.2μm. The activity of IL-2 liposome was detected by 'ConA induced T cell microdetermination'. The result showed good stability of IL-2 liposome,and its activity was significantly improved.