激光散射浊度法测定剪切诱导血小板聚集

MEASUREMENT OF SHEAR INDUCED PLATELET AGGREGATION (SIPA)BY THE METHOD OF LASER SCATTERING TURBIDITY

剪切诱导血小板聚集（ＳＩＰＡ）对动脉血栓性疾病的防治有十分重要的意义。利用激光散射浊度法的测量原理，在北京世帝科学仪器公司ＬＧ—Ｂ—１９０红细胞变形／聚集测试仪的基础上，经改进研制成功了测定剪切诱导血小板聚集的实验装置；该装置能方便地控制剪切率与剪切时间，并能连续记录血小板在剪切过程中的聚集情况。是研究ＳＩＰＡ的机理及抗ＳＩＰＡ的机理及抗ＳＩＰＡ药理的有力工具。

According to the principle of scattering turbidity, based on the Cytorheometer LG-B- 190 of Beijing Steellex Instrument Co., an apparatus of measuring SIPA is developed.Both shear rate and shear duration can be accurately controlled by a software. The process of SIPA can be continously monitored. The apparatus would be a powerful tool for studies of the mechanism of SIPA and of anti-SIPA pharmacology.