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亚油酸酰化胰岛素的制备及飞行质谱分析

Preparation and MALDI-TOF-MS analysis of the acylated insulin with linoleic acid
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摘要 Linoleoyl benzotriazole was synthesized from linoleic acid and benzotriazole by means of dicyclohexylcarbodiimide coupling method and characterized by FT-IR and 1H NMR.Linoleoyl insulin was prepared by chemical modification of insulin with linoleoyl benzotriazole without using any specific protecting group.MALDI-TOF-MS analysis showed that the modification of insulin was successful and the monoacylated insulin was the major product.A little diacylated insulin was observed and no triacylated insulin was detected. Linoleoyl benzotriazole was synthesized from linoleic acid and benzotriazole by means of dicyclohexylcarbodiimide coupling method and characterized by FF - IR and ^1 H NMR. Linoleoyl insulin was prepared by chemical modification of insulin with Iinoleoyl benzotriazole without using any specific protecting group. MALDI - TOF - MS analysis showed that the modification of insulin was successful and the monoacylated insulin was the major product. A little diacylated insulin was observed and no triacylated insulin was detected.
作者 黄涛 黄开勋
机构地区 中南民族大学化学与材料学院分析化学国家民委重点实验室 华中科技大学化学系
出处 《化学研究与应用》 CAS CSCD 北大核心 2006年第7期834-836,共3页 Chemical Research and Application
基金 湖北省教育厅科研基金资助项目(2003A007)
关键词 亚油酸 苯并三唑 亚油酰苯并三唑 胰岛素 亚油酰胰岛素 Iinoleic acid benzotriazole Iinoleoyl benzotriazole insulin linoleoyl insulin
分类号 O629.9 [理学—有机化学]
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参考文献10

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化学研究与应用
2006年 第7期

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