摘要
Linoleoyl benzotriazole was synthesized from linoleic acid and benzotriazole by means of dicyclohexylcarbodiimide coupling method and characterized by FT-IR and 1H NMR.Linoleoyl insulin was prepared by chemical modification of insulin with linoleoyl benzotriazole without using any specific protecting group.MALDI-TOF-MS analysis showed that the modification of insulin was successful and the monoacylated insulin was the major product.A little diacylated insulin was observed and no triacylated insulin was detected.
Linoleoyl benzotriazole was synthesized from linoleic acid and benzotriazole by means of dicyclohexylcarbodiimide coupling method and characterized by FF - IR and ^1 H NMR. Linoleoyl insulin was prepared by chemical modification of insulin with Iinoleoyl benzotriazole without using any specific protecting group. MALDI - TOF - MS analysis showed that the modification of insulin was successful and the monoacylated insulin was the major product. A little diacylated insulin was observed and no triacylated insulin was detected.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2006年第7期834-836,共3页
Chemical Research and Application
基金
湖北省教育厅科研基金资助项目(2003A007)