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肿瘤相关巨噬细胞与胃癌血管生成及转移关系 被引量：2

Relationship of Tumor Associated Macrophages with Angiogenesis and Metastasis in Gastric Cancer
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摘要 [目的]探讨肿瘤相关巨噬细胞(TAMs)浸润与胃癌血管生成及转移的关系。[方法]采用免疫组织化学法检测51例胃癌组织微血管密度(MVD)、TAMs和血管内皮生长因子(VEGF)的表达。[结果]TAMs的表达在高分化癌组织中明显低于中-低分化组(P<0.05);淋巴结转移组高于无淋巴结转移组(P<0.05);TAMs与VEGF及MVD均呈正相关(r=0.74,P<0.01;r=0.58,P<0.05)。[结论]胃癌组织中TAMs在血管生成及肿瘤转移中可能起重要作用。
作者 蔡方 赵勇 赵文丽
机构地区 广东医学院附属惠州中心人民医院
出处 《中国肿瘤》 CAS 2006年第7期476-477,共2页 China Cancer
基金 广东省惠州市 科技计划:项目(2006Y003)
关键词 胃肿瘤 血管内皮生长因子 巨噬细胞 微血管密度
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1石小燕,马丁.淋巴管生成与肿瘤转移研究进展[J].国外医学（肿瘤学分册）,2004,31(9):667-670. 被引量：9
  • 2王建伟,刘颖斌,曹明智,方河清,朱锦辉,姚晓霖,彭淑牖.乳腺癌肿瘤相关巨噬细胞与血管生成关系的研究[J].实用肿瘤杂志,2005,20(1):46-48. 被引量：5
  • 3王天宝,董文广,韩方海,李兆亭.血管内皮生长因子受体-3与胃癌临床病理因素的关系[J].中国普外基础与临床杂志,2004,11(4):341-343. 被引量：5
  • 4Fasciani A,Dambrogio G,Bocci G,et al.High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata[J].Mol Hun Reprod,2000,6(1):50.
  • 5Lukits J,Timar J,Juhasz A,et al.Progression difference between cancers of the larynx and hypopharynx is not due to tumor size and vascularization[J].Otolaryngol Head Neck Surg,2001,125:18-22.
  • 6李红霞,苌新明,和水祥,宋政军.COX-2、VEGF的表达和胃癌血管生成的关系[J].西安交通大学学报（医学版）,2003,24(5):471-473. 被引量：12
  • 7Schoppmann SF,Birner P,Stockl J,et al.Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis[J].Am J Pathol,2002,161(3):947-956.
  • 8Kago J,Kakeji Y Sumiyoshi Y,et al.Angiogenesis and macrophage infilteation in Borrmann type Ⅳ gastric cancer[J].Fukuoka Igaku Zasshi,2001,92(9):334-339.
  • 9Bingle L,Brown NJ,Lewis CE.The role of tumour-associated macrophages in tumour progression:implications for new anticancer therapies[J].J Pathol,2002,196(3):254-265.

二级参考文献58

  • 1Mattila MM, Ruohola JK, Karpanen T, et al. VEGF-C-induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer, 2002,98(6):946-951.
  • 2Stacker SA, Achen MG, Jussila L, et al. Metastasis: lymphangiogenesis and cancer metastasis. Nat Rev Cancer, 2002, 2(8) :573-583.
  • 3Maula S-M, Luukkaa M, Gronman R, et al. Intratumoral lymphatic are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res, 2003,63(8): 1920-1926.
  • 4Straume O, Jackson DG, Akslan LA. Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res,2003,9(1 ):250-256.
  • 5Yokoyama Y, Sato S, Futagami M, et al. Prognostic significance of vascular endothelial growth factor and its receptor in endometrial carcinoma. Gynecol Oncol,2000,77(3) :413-418..
  • 6Yonemura Y, Fushida S, Bando E, et al. Lymphangiogenesis and the vascularendothelial growth factor receptor( VEGFR)-3 in gastric cancer. Eur J Cancer, 2001,37(7) :918-923.
  • 7Bimer P, Obermair A, Schindl M, et al. Selective immunohistcehemical staining of blood and lymphatic vessels reveals independent prognostic influence of blood and lymphatic vessels invasion in early-stage cervical cancer. Clin Cancer Res,2001,7(1):93-97.
  • 8Schoppmann SF, Bimer P, Studer P , et al. lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer. Anticancer Res, 2001,21 (4A) :2351 -2355.
  • 9White .JD, Hewett PW, Kosuge D, et al. Vascular endothelial growth fantor-D expression is an independent prognostic marker for survival in colorectal caroinoma. Cancer Res, 2002, 62(6):1669 -1675.
  • 10Munoz Guerra MF, Marazuela EG, Martin Villar E, et al. Prognostic significance of intratumoral lymphangiogenesis in squamous cell carcinoma of the oral cavity. Cancer, 2004,100(3):553-560.

共引文献26

同被引文献31

  • 1吴敏,徐幼龙,张世统,周金良.树突状细胞浸润、微血管密度在进展期胃癌中的预后意义[J].实用肿瘤学杂志,2005,19(3):167-169. 被引量：1
  • 2郭双平,王文亮,李擒龙.肿瘤相关性巨噬细胞与胃癌浸润和转移的关系[J].临床与实验病理学杂志,2007,23(2):233-234. 被引量：3
  • 3Stuelten CH, DaCosta Byfield S, Arany PR, et al. Breast cancer cells induce stromal fibroblasts to express MMP - 9 via secretion of TNF - alpha and TGF - beta [ J ]. J Cell Sci ,2005,118 ( pt 10 ) :2143 - 2153.
  • 4Martinez FO, Helming L, Gordon S. Alternative activation of maerophages : an immunologic functional perspective [ J ]. Annu Rev Immunol,2009,27 (2) :451 - 483.
  • 5Pollard JW. Trophic macrophages in development and dis- ease[J].Nat Rev Immunol,2009,9(4) :259 -270.
  • 6Zhang H, Issekutz AC. Down - modulation of monocyte transendothelial migration and endothelial adhesion mole- cule expression by fibroblast growth factor: reversal by the anti- angiogenic agent SU6668 [ J ]. Am J Pathol, 2002, 160 (6) :2219 - 2230.
  • 7Joyee JA, Pollard JW. Mieroenvironmental regulation of me- tastasis [ J ]. Nat Rev Cancer,2009,9 (4) :239 - 252.
  • 8Merck E, Gaillard C, Seuiller M, et al. Ligation of the FcR gamma chain - associated human osteoclast - associated re- ceptor enhances the proinflammatory responses of human monocytes and neutrophils [J]. J Immunol,2006,176(5): 3149 -3156.
  • 9Koga J, Kakeji Y, Sumiyoshi Y, et al. Angiogenesis and mac- rophage infiltration in Borrmann type IV gastric cancer [ J ]. Fukuoka Lgaku Zasshi ,2001,92 (9) : 334 - 339.
  • 10Wu H, Xu JB, He YL, et al. Tumor - associated macropha- ges promote angiogenesis and lymphangiogenesis of gastric cancer [ J ]. J Surg Oncol, 2012,106 ( 4 ) :462 - 468.

引证文献2

二级引证文献3

中国肿瘤
2006年 第7期

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