摘要
作者观察了严重早期烧伤及假伤（正常）血浆提取物（分别以ＢＰＴ及ＮＰＥ表示）对离体灌流正常豚鼠乳头肌细胞电活动的影响。结果发现：高、中、低３种浓度的ＢＰＴ，①均可使静息电位减小，其时程曲线略呈“Ｓ”形，其潜伏期有明显的浓度依赖性；②均可引起乳头肌节律不整的自发兴奋；③高浓度ＢＰＴ明显使动作电位幅度（ＡＰＡ）降低，中、低浓度的ＢＰＴ对ＡＰＡ及最大除极速度均无明显影响；④ＢＰＴ对复极化时程ＡＰＤ１０的影响不大，但使ＡＰＤ５０及ＡＰＤ９０显著延长，使动作电位波形在复极化初期出现明显的凹陷和平台期延长；⑤高浓度ＮＰＥ有相当于低浓度ＢＰＴ的生物效应。提示ＢＰＴ可能直接影响心肌细胞Ｋ＋、Ｃａ２＋的转运。
Theefectsofplasmaextractofnormal(NPE)andburned(BPT)guineapigsonbioelectricactivityofisolatednormalguineapig′spapilarymusclewereobservedandcompared.Theburnedanimalssuferfor35%fulthicknessburninjury.After8hthere-sultsareshownasfolows.1.AlBPTofhigh,middleandlowconcentrationsandNPEinhighconcentratonsygnificantlydecreasetherestingpotential(RP).ThevariationoftimecourseofRPexpressesastheshapeof“S”.Thereisanobviousconcentrationdependencefortheresponselatency.2.ThearrhythmicspontaneousexcitationmaybeevokedbyeitherBPTofthreeconcentrationsorNPEinhighconcentration.3.ThehighconcentrationofBPTdecreasestheamplitudeofactionpotential(APA)obviously,otherBPTconcentrationsandalNPEhavenoefectonAPAandmaximaldepolarizationrate(Vmax).4.BothBPTandNPEhavenoefecton10%repolarizationduration(APD10),butBPTobviouslyprolongedthe50%and90%repolarizationduration(APD50,APD90)respectively.Thewaveformoftheactionpotentialshowedanobviousconcaveatearlyrepolarizationcourseandaprolongedplateau.5.ThebiologicalefectofNPEinhighconcentrationcorespondswiththatofBPTinalowconcentration.TheseresultssuggestthatBPTmaybeabletodirectlyinfluencethetransportofK+andCa2+andmayhavelitleefectonNa+transportacrossthecelmem-brane.
基金
国家自然科学基金
