人参皂甙对精神分裂症动物模型大鼠记忆保持的影响

Effect of Ginsenosides on Memory Retention of Rats in Animal Models of Schizophrenia

目的:探讨人参皂甙(Ginsenosides,GS)对精神分裂症动物模型大鼠记忆保持的影响。方法:入组大鼠随机分为实验组和对照组,实验组给予人参皂甙灌胃,对照组给予生理盐水灌胃,治疗第5天后,两组大鼠同时注射药物MK801(5-甲基二氢二苯并环庚稀亚氨马来酸或地卓西平马来酸盐)建立精神分裂症的动物模型;在用MK801前、第1、3、5天,采用主动回避反应(AAR)和一次性被动回避反应(OPAR)观察各组大鼠的行为变化。结果:给予MK801后,实验组大鼠ARR第1、3、5习得率明显高于对照组(231·79±18·90/158·28±6·78,134·86±15·49/92·29±9·22,81·64±17·29/36·08±17·12,t=10·35、6·68、5·29,P<0·01),且消退也慢于对照组(199·09±15·78/169·44±13·72,128·94±10·80/108·15±13·45,98·06±11·50/42·33±20·08,t=4·01、3·41、6·81,P<0·01)。给MK801后,OPAR训练到第5天,大鼠的步入潜伏期实验组显著大于对照组(79·25±13·49/51·33±11·09,t=4·53,P<0·01),触电次数和触电时间显著低于对照组(4·25±1·49/8·33±2·09,7·25±3·49/27·33±6·09,t=4·49、8·10,P<0·01)。结论:连续口服GS对精神分裂症动物模型大鼠记忆保持能力受损有明显保护作用。在一定的时间内,这种保护作用随动物模型时间的延长面增强。

Objective： To explore the effect of ginsenodels on the memory retention of rats of animal models of schizophrenia. Methods： The rats in experiment were divided into experimental group and control group, the rats in the experimental group were orally given Ginsenosides, and rats in control group were given normal saline. Both groups were treated for 5 days, then given injection of MK801 to establish animal models of schizophrenia. Before （d0） , during （d1, d3） and after （d5） MK801. Several behavior models such as active avoidance reaction （AAR） and once passive avoidance reaction （ OPAR ） were used to research the process of learning and memory before and after experimental. Results： In the active avoidance reaction, the rats of experimental group were used to increase, and the fade away slowed to the rats of controls groups significantly （ 231.79 ± 18. 90/158.28 ± 6. 78, 134. 86 ± 15.49/92. 29 ± 9. 22, 81.64 ± 17. 29/36. 08 ± 17. 12, t = 10. 35, 6. 68, 5. 29, P 〈0. 01 ） . In the once passive avoidance reaction, after establishing the animal models of schizophrenia , through the training of 5 days , the step through latent of the experiment group was longer （ 199.09 ± 15.78/169.44 ± 13.72, 128.94 ± 10.80/108. 15 ± 13.45, 98.06 ± 11.50/42. 33 ± 20. 08, t = 4. 01, 3.41, 6. 81, P 〈 0. 01 ）, the number and time of electrified were less than the control group （4. 25 ± 1.49/8. 33 ±2. 09, 7.25 ±3.49/27. 33 ±6. 09, t =4. 49, 8. 10, P 〈0. 01 ） o.Conclusion： Ginsenosides have memory retention facilitating effect on rats in animal models of schizophrenia, the effect may be enhancod by the increase of duration of animal models of schizophrenia.