舍曲林合并米诺环素治疗慢性前列腺炎伴抑郁状态

Sertraline Combined with Minocycline for the Treatment of Chronic Prostatitis Complicated with Depression

目的:研究舍曲林合并米诺环素对慢性前列腺炎伴抑郁状态的临床疗效。方法:将90例慢性前列腺炎伴抑郁状态的患者随机分为2组,一组采用米诺环素加舍曲林治疗,另一组采用米诺环素加安慰剂治疗,疗程5周。结果:米诺环素加舍曲林组和米诺环素加安慰剂组治疗慢性前列腺的总有效率分别为55·8%和27·3%(χ2=6·17,P<0·05),治疗抑郁状态的总有效率分别为79·1%、29·5%(χ2=21·5,P<0·01)。结论:对慢性前列腺炎伴抑郁状态患者,给予米诺环素治疗慢性前列腺炎的同时,给予舍曲林抗抑郁治疗,能取得良好的综合疗效。

Objective： To investigate the effect of Sertraline combined with minocycline for the treatment of chronic prostatitis complicated with depression. Methods： A total of 90 patients with the diagnosis of chronic prostatitis complicated with depression were randomly divided into two groups. The study group received combined treatment of minocyeline and sertraline, and the control group received combined treatment of minoeycline and placebo. Results： The total effective rate of chronic prostatitis of sertraline group and placebo group were 55. 8 % and 27.3 % （χ^2 = 6. 17, P 〈 0. 05） . The total alleviating rate of depression of sertraline group and placebo group were 79. 1% and 29. 5% { X2 =21.5, P 〈0.01 ） . Conclusion： Sertraline can enhance the treatment effect of minocyeline for chronic prostatitis complicated with depression.