期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肾上腺髓质素与K_(ATP)通道的研究进展 被引量：1

下载PDF
导出
摘要 肾上腺髓质素(ADM)是一种心血管活性多肽,具有扩血管、抑制血管平滑肌细胞增殖等广泛的生物学效应,特别是扩张血管作用更为突出。ATP敏感钾通道(KATP)是由一类较广泛分布的内向整流钾通道Kir和硫脲类受体SUR亚基共同组成,在生理及某些病理条件下KATP参与血管张力的调节,并受多种因素的调控,胞内二磷酸核苷酸(NDPs)、钾通道开放剂(KCOs)等可激活通道,而ATP和硫脲类药物则特异性抑制通道的开放。ADM的扩血管作用多与KATP有关,具体作用机制目前尚不清楚。
作者 薛明 李家富
机构地区 四川省泸州医学院附属医院心血管病研究室
出处 《国际心血管病杂志》 2006年第4期255-257,共3页 International Journal of Cardiovascular Disease
关键词 肾上腺髓质素 ATP敏感钾通道 血管平滑肌 血管扩张
分类号 Q46 [生物学—生理学]
  • 相关文献

参考文献16

  • 1[1]Kitamura K,Kangawa K,Kawamooto M,et al.Adrenomedullin:a novel hypotensive peptide isolated from hu man pheochromocytoma[J].Biochem Biophys Res Commun,1993,192 (1):553-560.
  • 2[2]Ishiyama Y,Kitamura K,Ichiki Y,et al.Hemodynamic effects of a noval hypotension peptide,human adrenomullin,in rats[J].Eur J Pharmacol,1993,241(2-3):271-273.
  • 3[3]Kitamnra K,Sakata J,Kangawa K,et al.Cloning and characterization of DNA encodina precursor for human adrenomedullin[J].Biochem Biophys Res Commun,1993,194(2):720-725.
  • 4[4]Ichiki Y,Kitamura K,Kangawa K,et al.Distribution and charaterization of immunoreactive adrenomedullin in human tissue and plasma[J].FEBS Lett,1994,338(1):6-10.
  • 5[5]Noma A.ATP-regulated K+ channels in cardiac muscle[J].Nature,1983,305(5930):147-148.
  • 6[6]Seino S.ATP-sensitive potassium channels:a model of heteromultimeric potassium channel/receptor assemblies[J].Annu Rev Physiol,1999,61:337-362.
  • 7[7]Faivre JF,Findlay J.Effects of tolbutamide,glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle[J].Biochim Biophys Acta.1989,984(1):1-5.
  • 8[9]Nichols CG,Lederer WJ.Adenosine triphosphate-sensitive potassium channels in the cardiovascular system[J].Am J Physiol,1991,261 (6 Pt 2):1675-1686.
  • 9[10]Sabates BL,Pigott JD,Choe,et al.Adrenomedullin medi ates coronary vasodilation through adenosine receptors and KATP channels[J].J Surg Res,1997,67(2):163-168.
  • 10[11]Terata K,Miura H,Liu Y,et al.Human coronary arteriolar dilation to adrenomedullin:role of nitric oxide and K+ channels[J].Am J Physiol Heart Circ Physiol,2000,279(6):H2620-H2626.

二级参考文献25

  • 1Ikenouchi H, Kangawa K, Matsuo H, et al. Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes[J]. Circulation, 1997,95(9): 2318-2324.
  • 2Szokodi I, Kinnunen P, Tavi P, et al. Evidence for cAMP-independent mechanism mediating the effects of adrenomedullin, a new inotropie peptide [ J ]. Circulation,1998, 97(11): 1062- 1070.
  • 3Ihara T, lkeda U, Tate Y, et al. Positive inotropic effects of adrenomedullin on rat papillary muscle[J]. Eur J Pharmacol,2000, 390( 1 - 2) : 167 - 172.
  • 4Nakajima T, Takikawa R, Sugimoto T, et al. Effects of ealcitonin gene - related peptide on membrane currents in mammalian cardiac myocytes[J]. Pflugers Arch, 1991,419(6):644 - 650.
  • 5Sigrist S, Franco- Cereceda A, Muff R, et al. Specific receptor and cardiovascular effects of calcitonin gene - related peptide[J]. Endocrinology, 1986, 119(1) : 381 - 389.
  • 6Shimekake Y, Nagata K, Ohta S, et al. Adrenomedullin stimulates two signal transducfion pathways, cAMP accumulation and Ca^2+ mobolizafion, in bovine aorta endothelial cells[J].J Biol Chem, 1995, 270(9): 4412-4417.
  • 7Nagaya N, Nishikimi T, Uemaysu M, et al. Plamaa adrenomedullin as an indicator of progessis after acute myocardial infarctlon[J]. Heart, 1999,81(5): 483-487.
  • 8Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin:a novel hypotensive peptide isolated from human pheochromocytoma[J]. Biochem Biophys Res Commun, 1993, 192(2): 553 -560.
  • 9Nagaya N, Satch T, Nishikimi T, et al. Hemodynomic, renal and hormonal effects of adrcnomedullin infusion in patients with congestive heart failure[J]. Circulation, 2000, 101(5):498 - 503.
  • 10Zhang JJ, Yoshida H, Chao L, et al, Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis,and renal damage in hypertensive dahl salt- sensitive rats[J].Hum Gene Ther, 2000, 11(13): 1817- 1827.

共引文献1

同被引文献15

  • 1李剑,范维琥,敖红,黄爱民,罗心平,施海明,李勇.中药红景天对大鼠缺血心肌Flt-1、KDR及Tie-2表达的影响[J].中国中西医结合杂志,2005,25(5):445-448. 被引量：42
  • 2滕静如,熊佳鹏,肖诚,王昕.红景天的现代药理学研究进展[J].中国中医基础医学杂志,2006,12(4):319-320. 被引量：47
  • 3Cao L, Mooney DJ. Spatiotemporal control over growth factor signaling for therapeutic neovascularization[J]. Adv Drug Deliv Rev, 2007,59(13) :1340-1350.
  • 4Self WH, Storrow AB, Hartmann O, et al. Plasma bioactive adrenomedullin as a prognostic biomarker in acute heart failure[J]. Am J Emerg Med, 2016,34(2):257-262.
  • 5Kataoka Y, Miyazaki S, Yasuda S, et al. The first clinical pilot study of intravenous adrenomedullin administration in patients with acute myocardial infarction[J]. J Cardiovasc Pharmacol, 2010,56(4):413-419.
  • 6Siernsen DW, I)obrinen E, Han S, ct al. Vascular dysfunction in ted pulmonary hypertension is related to endothelin response and adrenomedullin concentration[J]. Am J Pathol, 2016,186(2) :259-269.
  • 7Yang J, Wang W, Dong M, et al. Effect of nucleoprotein factor-eB (NF-kappaB) in endothelial cells during high blood flow-associated pulmonary vascular remodeling on vasoactive substances adrenomedullin and prostacyclin[J]. Int J Clin Exp Med, 2015,8(8) : 13842 -13847.
  • 8Hu W, Zhou PH, Rao T, et al. Adrenomedullin attenuates interleukinlO-induced inflammation and apoptosis in rat Leydig cells via inhibition of NF-κB signaling pathway[J]. Exp Cell Res, 2015,339(2) :220 -230.
  • 9Chauhan M, Yallampalli U, I3anadakappa M, et al. Involvement of receptor activity-modifying protein 3 (RAMFr3) in the vascular actions of adrenomedullin in rat mesenteric artery smooth muscle cells[J]. Biol Reprod, 2015,93(5) : 116.
  • 10Nakamura R, Kato J, Kitamura K, et al. Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats [ J ]. Circulation, 2004,110(4) :426-431.

引证文献1

二级引证文献3

国际心血管病杂志
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部