摘要
目的:对重楼属(Paris)植物云南重楼(Paris polyphyllaSmith var.yunnanensis)的甾体皂苷类成分进行研究。方法:采用大孔树脂,硅胶柱色谱,Sephadex LH-20及RP-C18等技术分离纯化单体化合物,根据理化性质、波谱数据鉴定其结构。结果:从云南重楼乙醇提取物中分离并鉴定了9个甾体皂苷类化合物:(23S,25S)-3β,23,27-trihydroxyspirost-5-en-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(1)、重楼皂苷Ⅰ(2)、重楼皂苷Ⅱ(3)、(25R)diosgenin-3-O-β-D-glucopyranoside(4),(25R)diosgenin-3-O-α-L-arabinofuranosyl(1→4)-β-D-glucopy-ranoside(5),(25R)diosgenin-3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside(6),(25R)diosgenin-3-O-β-D-glu-copyranosyl(1→3)[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside(7),(25R)pennogenin-3-O-α-L-arabinofura-nosyl(1→4)[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside(8),(25R)pennogenin-3-O-α-L-rhamnopyranosyl(1→4)-α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside(9)。结论:化合物1为新化合物。
AIM: To investigate the chemical constituents of Paris polyphylla Smith vat. yunnanensis. METHOD: Compounds were isolated by silica gel, Sephadex LH-20 and RP-C18 column chromatography and the structures were elucidated on the basis of spectroscopic methods. RESULT: Nine compounds were isolated and identified as steroidal saponins: (23S, 25S)-3β3,23,27-trihydroxyspirost-5-en-3- O-β- D-glueopyranosyl- (1→6) -β- D-glueopyranoside ( 1 ), paris saponin Ⅰ (2), paris saponin Ⅱ ( 3 ), ( 25 R ) diosgenin-3- O-β- D-glueopyranoside ( 4 ), ( 25 R ) diosgenin-3- O-α- L-αrabinofuranosyl ( 1 → 4 )-β- D- glueopyranoside (5), ( 25 R ) diosgenin-3- O-α- L-rhamnopyranosyl ( 1 → 2) -β- D-glueopyranoside (6), ( 25 R ) diosgenin-3- O-β- D-glueopyranosyl ( 1 → 3 ) [ α- L-rhamnopyranosyl ( 1 → 2 ) ]-β- D-glueopyranoside ( 7 ), ( 25 R ) permogenin-3- O-α- L - arabinofuranosyl ( 1 → 4) [ a-L-rhamnopyranosyl ( 1 → 2)-β-D-glueopyranoside (8), ( 25R ) permogenin-3-O-α-L- rhamnopyranosyl ( 1→4)-α-L-rhamnopyranosyl ( 1→4)-[ α- L-rhamnopyranosyl(1→2) ]-β-D-glueopyranoside(9) . CONCLUSION: Compound 1 is a novel steroidal saponin.
出处
《中国天然药物》
SCIE
CAS
CSCD
2006年第4期264-267,共4页
关键词
重楼属
云南重楼
甾体皂苷
Paris
Paris polyphylla Smith vat. yurmanensis
Steroidal saponins