复杂肠瘘切除吻合术围手术期大剂量应用蛇毒血凝酶的临床观察

Perioperative use of large dosage of hemocoagulase in complicated fistula

目的研究注射用蛇毒血凝酶在普通外科中大型手术中止血的有效性及安全性。方法选取本科行肠瘘手术治疗的住院患者48例,随机分为3组:大剂量组,小剂量组,对照组,观察3组患者术中伤口渗血及术后渗血况。结果应用血凝酶组患者术中伤口渗血量较对照组少,术后引流血量也较少。大剂量应用血凝酶组与小剂量组患者均未出现用药相关并发症。结论大剂量应用蛇毒血凝酶能减少中大型外科手术伤口术中及术后的渗血,疗效确切,未发现并发症及不良反应,临床应用安全。

Objective To evaluate the efficiency and safety of hemocoagulase used in general surgery. Methods Forty - eight with intestintal fistula in our department were randomly divided into large dose of hemocoagulase group, low dose of bemocoagulase group and control group. Patients in large dose group administrated hemocoagulase one day and 30 min before operation, during opertation, and 1 - 2 days postoperation; Those in low dose group administered hemocoagulase only 30 min before operation, during operation, and postoperation; And those in control group administered Etamsylate, Aminomethylbenzoic Acid and Vitamin K1. The conditions of wound bleeding during and after operation were observed. Results As compared with the control group, patients in trial groups had less wound bleedings and drainage, and no any complications occurred. Conclusion Use of large dose of hemocoagulase can reduce the wound bleeding during and after operation. The curative effectiveness was satisfactory and no complications and side effects occurred.