大剂量化疗在股骨恶性肿瘤保肢治疗中的应用

Application of Massive Dose Chemotherapy in the Limb Salvage Treatment of Femoral Malignant Tumor

目的：探讨股骨恶性肿瘤保肢治疗的化疗方法及其可行性。方法：对11例股骨恶性肿瘤病例，通过术前穿刺活检、定性、Ennecking分期、大剂量化疗；术中瘤段切除人工关节置换、瘤骨灭活再植等手术方法；术后大剂量冲击化疗等三个阶段的综合治疗。结果：Ⅱ例病人均随访10个月～5年（平均3年3个月）。8例无复发，肢体功能优良率达72％。结论：通过三个阶段的综合治疗认为大剂量化疗是股骨恶性肿瘤达到保肢的有效措施。

Objective： To discuss the chemotherapy methods and the feasibility in the limb salvage treatment of femoral malignant tumor. Methods： Eleven eases of femoral malignant tumor were analyzed in retrospect by general treatment of the three stages . They were preoperative aspiration biopsy, qualitification, Ennecking stages, massive dose chemotherapy; intraoperative resection of the tumor-loading segment and the replacement of the endoprosthesis, tumor inactivated replantation; post-operative massive dose impact chemotherapy and so on. Results： All the eases were followed-up 10-60 months （average 39 months）.Eight cases had no relapse. The excellent rate of the limb function was 72 %. Conclusion： Through the general treatment of the three stages, we think massive dose chemotherapy is an effective measure for limb salvage in femoral malignant tumor.