活性氧参与艾滋病发病的机理

Reactive Oxygen Species Participate the Pathogenesis of AIDS

ＨＩＶ的长期感染，使得患者体内活性氧大量积累，形成了氧胁迫．各种活性氧介导的氧胁迫，能够激活转录因子ＮＦｋＢ，从而刺激并促进ＨＩＶ的基因表达．同时氧胁迫还使得ＨＩＶ感染者机体功能陷入紊乱，表现为ＤＮＡ严重损伤，Ｃａ２＋失去细胞内外的平衡，酶系统遭到破坏，能量代谢受阻等诸多方面．应用抗氧化剂治疗艾滋病仍处于探索阶段．

During long period infection of HIV,plenty of reactive oxygen species are accumulatedin patients, and then oxidative stress forms.Oxidative stress mediated by reactive oxygenspecies can activate a transcription factor, NFkBwhich in turn stimulates HIV gene expression.Besides, oxidative stress causes the disturbanceof biological functions of infected patients'bodies, such as DNA damage, loss of Ca2+homostasis, incurable destruction of enzyme system, block of energy production and so on, It is still at experimental stage to use antioxidants in AIDS therapy.