喹诺酮类药物重要中间体研究进展

Research Progress on The Important Intermediates of Quinolone Antibacterial Agents

介绍了一些喹诺酮类药物生产和市场近况,对合成喹诺酮类药物的一些重要中间体或原料以及它们的最新发展、药效和应用情况也给予了较详细论述。有一些中间体,如合成氧氟沙新、环丙沙新的2,4-二氯氟苯和2,3,4,5-四氟苯甲醛中间体、和合成洛美沙新等的2,3,4-三氟硝基苯中间体等,由于它们市场需求越来越大,对它们的合成路线也给予了较详细论述。对中间体的研究开发表明,由精细化工厂生产医药中间体和原料药是精细化工行业的发展趋势,前景十分广阔。

In this paper , some of important intermediates of quinolone antibacterial agents were summarized in detail .Such as 2,6-dibromoaniline, 2,4-dichlorflurobenzene, 2,4-dichloro-5-fluorobenzoic acid, 2,4-difurorobenzaldehyde, 1,2,3-trichlorobenzene, 3-acetamidoprrolidine etc. Analysis its market demand, development trend and technological progress at abroad and home. Some of intermediate, for example, 2,4- dichlorofluorobenzene for synthesizing ciprofloxacin, a broad-spectrum anddofics, with the increasing consumpdon of ciprofloxacin demand for 2,4-dichlorofluorobenzene and 2,3,4.5-tetrafluorobenzoic acid for synthesizing Ofloxacin increasing at home and abroad, were introduced especially . Therefore, quinolone drug has a good future. The development trend of fine chemical industry is the fine chemical plants to produce the intermediates and bulk pharmaceuticals.