冠心病合并睡眠呼吸暂停综合征患者的临床特点

Clinical Features of Patients With Coronary Heart Disease and Sleep Apnea Syndrome

目的:了解冠心病合并睡眠呼吸暂停综合征患者的发生率,并探讨其临床特点。方法:对2004年11月-2005年2月入住我中心行冠状动脉造影的患者,进行多导睡眠呼吸监测,并对其临床症状进行分析。结果:175例患者接受检查入选,冠状动脉造影确诊冠心病患者135例,其中合并睡眠呼吸暂停综合征62．2％(84／135);非冠心病患者40例,其中合并睡眠呼吸暂停综合征40％(16／40),P<0．005。冠心病合并睡眠呼吸暂停综合征与冠心病不合并睡眠呼吸暂停综合征两组之间嗜睡评分、腰臀比、夜间胸痛或憋醒、夜尿增多、晨起口干有明显差别,P< 0．05。Logistic回归分析显示体重指数、夜尿增多、夜间胸痛或憋醒是冠心病患者合并睡眠呼吸暂停综合征的危险因素。结论:冠心病合并睡眠呼吸暂停综合征发病率高,应对冠心病患者进行睡眠呼吸监测,尤其夜间反复发作胸痛憋气、夜尿增多、肥胖的患者应进行睡眠呼吸监测,尽早进行诊断及治疗。

Objective： To determine the incidence of sleep apnea syndrome （SAS） in patients with coronary artery disease （CAD）, and to assess the clinical features of patients with CAD and SAS. Methods： Sleep-breath monitoring was performed in all patients undergoing coronary angiography from November 2004 to February 2005 in our center. The clinical features were analyzed. Results： In 175 consecutive inpatients, angiography and sleep-breath monitoring were performed. 135 patients were diagnosed as having CAD. Sleep-breath monitoring showed that there were 62.2% of the CAD patients had SAS （84/135） and 40% patients of the patients with no known CAD had SAS （16/40） （ P 〈 0. 005 ）. There were significant differences of BMI, the ratio of waistline/hipline, and the frequencies of nocturnal angina, nocturnal polyuria between the two groups. Conclusions ： There is a high incidence of SAS in patients with CAD and sleep-breath monitoring should be performed in patients with CAD, especially for patients with clinical features such as higher BMI, frequent nocturnal angina, and nocturnal polyuria.