结直肠癌中组织因子和p53蛋白表达的相关性及其意义

Correlation and significance of tissue factor and p53 protein expression in colorectal carcinoma

目的研究组织因子(TF)和p53蛋白在结直肠癌组织中表达的相关性并探讨其意义。方法应用免疫组织化学方法检测43例结直肠癌标本中TF和p53蛋白的表达情况。结果43例结直肠癌组织中19例(44·2%)TF表达阳性,21例(48·8%)p53蛋白表达阳性;TF表达阳性者中78·9%(15/19)淋巴结转移阳性,p53蛋白表达阳性者中85·7%(18/21)淋巴结转移阳性,两者的表达均与淋巴结转移密切相关(r=0·414和0·588,P<0·01);p53蛋白阳性表达组TF阳性率为66·7%(14/21),而p53蛋白阴性表达组TF阳性率为22·7%(5/22),二者呈正相关(r=0·442,P=0·003)。结论结直肠癌组织中TF和p53蛋白表达与肿瘤淋巴转移密切相关,TF的表达与p53蛋白的表达具有显著相关性。

Objective To investigate the correlation of tissue factor （TF） and p53 protein expression in colorectal carcinoma. Methods The expression of TF and p53 protein was studied by immunohistochemistry in 43 cases of primary colorectal carcinoma. Results TF expression was positive in 44. 2% （19/43） of cases, and p53 protein expression was positive in 48. 8% （21/43） of cases. The lymph node metastatic rate was 78. 9% （15/19） in patients with positive expression of TF, and 85.7% （18/21） in patients with positive p,53 protein expression. Both TF and p53 protein expressions showed significant correlation with lymph node metastasis （x^2= 8. 96 and 14. 88, P〈0. 001）. The TF positive expression rate in p,53 protein positive cases was 66. 7%（14/21）, and in p53 negative cases was 22. 7% （5/22）, TF expression was correlated with p53 protein expression （r=0.442, P=0.003）. Conclusion The expressions of TF and p53 protein were closely related with the lymph node metastasis of colorectal carcinoma, also the expression of TF was significantly correlated with p53 protein expression.