溶脲脲原体、沙眼衣原体感染与男性不育随机对照实验的Meta分析

Correlation of Ureaplasma urealyticum and Chlamydia trachomatis Infections with Male Sterility: A Meta-analysis of Radomized Control Trials

目的：利用Meta分析法探讨中国人群溶脲脲原体、沙眼衣原体感染与男性不育的关系。方法：制定原始文献的纳入标准、排除标准及检索策略，在中国生物医学文摘（CBMA）、中国学术期刊全文数据库（CNKI）内进行病例对照研究的检索和资料提取。应用RevMan软件对有关溶脲脲原体（Uu）、沙眼衣原体（Ct）感染与男性不育关系的文献进行质量评价及综合定量评价。以优势比（OR）及其95％可信区间（95％CI）为效应尺度，并进行敏感性分析。结果：共检索到相关文献88篇，排除60篇，符合纳入标准28篇进入Meta分析。Uu、Ct感染与男性不育关系的合并OR值分别为ORUu：4．73（95％CI：3．77～5．94）、ORCt：4．59（95％CI：3．24～6．50）。结论：Uu、Ct感染为国人男性不育的重要危险因素。

Objective： To evaluate the correlation of Ureaplasma urealyticum （Uu） and Chlamydia trachomatis （Ct） infections with male sterility. Methods ： Data from CBMA and CNKI were searched and studies were made for the correlation of Uu and Ct infections with male sterility by retrieval strategy worked out according to the Collaborative Review Group search strategy. The results were expressed as odds ratio （OR） and 95 % confidence intervals（95 % CI）. The results of 28 clinical controlled trials from 1994 to 2005 were analyzed by software RevMan 4.2. Odds ratio（OR） was applied to the evaluation of the correlation between Uu infection and male sterility. Results ： Eighty-eight relative trials were retrieved, of which 28 were included in the Meta-analysis. The combined ORs of Uu and Ct infections to male sterility were ORUu：4.73（95% CI： 3.77 ～5.94） and ORCt ：4. 59（95% CI：3.24 ～6.50）. Conclusion： Uu and Ct infections are very important risk factors of sterility in Chinese men.