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G蛋白偶联受体激酶的研究进展 被引量：2

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摘要 G蛋白偶联受体激酶(GRKs)属丝氨酸／酪氨酸蛋白激酶家族,其亚型广泛存在于各种组织, 能特异地使活化的G蛋白偶联受体(GPCR)发生磷酸化及脱敏化,从而终止后者介导的信号转导通路．现就G蛋白偶联受体激酶的结构、种类及分布、生物学功能及与疾病关系的新进展进行总结与概括,并对其发展进行了展望．
作者 杨雯 夏时海
机构地区 武警医学院附属医院消化内科胰腺中心
出处 《世界华人消化杂志》 CAS 北大核心 2006年第16期1602-1607,共6页 World Chinese Journal of Digestology
基金 国家自然科学基金资助课题 No.30300456
关键词 G蛋白偶联受体激酶 磷酸化 受体脱敏
分类号 R341 [医药卫生—基础医学]
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参考文献44

  • 1Pitcher JA,Freedman NJ,Lefkowitz RJ.G proteincoupled receptor kinases.Annu Rev Biochem 1998;67:653-692
  • 2Rapacciuolo A,Suvarna S,Barki-Harrington L,Luttrell LM,Cong M,Lefkowitz RJ,Rockman HA.Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.J Biol Chem 2003; 278:35403-35411
  • 3Fredriksson R,Hoglund PJ,Gloriam DE,Lagerstrom MC,Schioth HB.Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.FEBS Lett 2003; 554:381-388
  • 4Chen CK,Zhang K,Church-Kopish J,Huang W,Zhang H,Chen YJ,Frederick JM,Baehr W.Characterization of human GRK7 as a potential cone opsin kinase.Mol Vis 2001; 7:305-313
  • 5Benovic JL,Strasser RH,Caron MG,Lefkowitz RJ.Beta-adrenergic receptor kinase:identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.Proc Natl Acad Sci USA 1986; 83:2797-2801
  • 6Pitcher JA,Inglese J,Higgins JB,Arriza JL,Casey PJ,Kim C,Benovic JL,Kwatra MM,Caron MG,Lefkowitz RJ.Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.Science 1992;257:1264-1267
  • 7Pitcher JA,Touhara K,Payne ES,Lefkowitz RJ.Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.J Biol Chem 1995;270:11707-11710
  • 8Holmes KD,Babwah AV,Dale LB,Poulter MO,Ferguson SS.Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases.J Neurochem 2006; 96:934-949
  • 9Gainetdinov RR,Premont RT,Caron MG,Lefkowitz RJ.Reply:receptor specificity of G-protein-coupled receptor kinases.Trends Pharmacol Sci 2000; 21:366-367
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二级参考文献36

  • 1Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annu Rev Biochem, 1998;67:653-92.
  • 2Weiss ER, The cloning of GRK7, a candidate cone opsin kinase, from cone and rod-dominant mammalian retinas, Mol Vis, 1998,4:27.
  • 3Ji TH, Grcssmann M, Ji I. G protein-coupled receptors. J Biol Chem, 1998,273(20) :17299-302.
  • 4Clapham DE, Neer EJ. G protein βγ subunits. Annu Rev Pharmaol Toxicol , 1997;37: 167-203.
  • 5Cong M, Perry SJ, Lin FT, Regulation of membrane targeting of the GRK2 by PKA and its anchoring protein AKAP79, J Biol Chem, 2001;276(18): 15192-9.
  • 6Krasel C, Dammeier S, Winstel R. Phosphorylation of GRK2 by PKC abolishes its inhibition by calmodulin. J Biol Chem,2001;276(3) : 1911-5.
  • 7Freeman JL, Pollard TD, Lefkowitz RJ. Regulation of GRK5 by actin. J Biol Chem, 1998;273(32);20653-7.
  • 8Freeman JL, Pitcher JA, Li X. Alpha-actinin is a potent regulator of GRKs activity and substrate specificity in vitro. FEBS Lett, 2000;473(3) :280-4.
  • 9Pronin AN, Satpaer DK, Slepak RZ. Regulation of GRKs by calmodulin and localization of the calmodulin binging domain. J Biol Chem, 1997;272(29) : 18273-80.
  • 10Iacovelli L, Sallese M, Blasi AD. Regulation of GRK subunits by calcium sensor protein. FASEB J, 1999 ; 13(1) : 1-8.

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二级引证文献18

世界华人消化杂志
2006年 第16期

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