摘要
目的:建立兔VX2肾癌模型,观察模型动物在螺旋T,MRI及肾动脉造影的影像学表现.方法:新西兰大白兔20,采取VX2瘤块种植法成瘤,分别在不同时段行螺旋CT,RI及肾动脉造影检查.结果:实验组成瘤率100%.肿瘤在螺旋CT平扫时呈等密度或低密度灶,增强后呈低密度结节,边缘环形强化.MRI平扫时,肿瘤在T1WI和T2WI上分别为较均匀低信号和稍高信号灶,3wk后肿瘤因坏死、液化而表现为高低密度混合型结节.肾动脉插管造影,VX2肾癌呈丰富血供表现.结论:兔VX2肾癌模型的最佳干预期是植瘤后2~3wk,螺旋CT筛检精确可靠,可作动态观测.
AIM: To establish rabbit VX2 renal carcinoma model and observe its manifestations in spiral CT, MRI and DSA. METHODS: VX2 renal carcinoma was induced in 20 New Zealand rabbits through VX2 carcinoma block transplantation, and then the carcinoma was examined through CT, MRI and angiography in different periods. RESULTS: Carcinoma formation rate was 100%. All the carcinomas were shown to be isointense or hypointense lesions through normal spiral CT. The carcinomas presented hypointense nodules and the enhanced edges through contrast-enhanced spiral CT. The carcinomas presented comparatively uniform hypointense lesions in T1-WI MR images and hyperintense lesions in T2-WI MR images. Three weeks later, the carcinomas showed mixed nodules of hypointense and hyperintense because of liquefaction and necrosis. In renal artery angiography VX2 carcinoma showed hypervascular. CONCLUSION: The best stage for experimental researches of rabbit VX2 carcinoma model is 2 -3 weeks after tumor transplantation. Spiral CT is suit to observe dynamicly and evaluate curative effect. The rabbit VX2 carcinoma model is fit for intervention research.
出处
《第四军医大学学报》
CAS
北大核心
2006年第7期584-586,共3页
Journal of the Fourth Military Medical University
基金
国家自然科学基金(30371831)