摘要
世界上大多数国家都制定了乙型肝炎(乙肝)免疫计划,这为预防性乙肝疫苗的研发提供了导向。从第一代血源性疫苗到重组乙肝疫苗,再到合成肽疫苗和DNA疫苗,乙肝疫苗的研制技术不断进步,其应用范围也已从预防扩展到治疗。本文分析了各国乙肝免疫计划与乙肝疫苗研发的关系,总结了预防性和治疗性乙肝疫苗的研发思路,并提出乙肝疫苗进一步研发的方向。
More than 100 countries have added hepatitis B vaccination to their routine immunization programmes. Hepatitis B vaccines progressed from blood vaccines to recombinant vaccines, then to peptide vaccines and DNA vaccines, to their functions extended from prophylactic to therapeutic. This article analyzes the relationship between hepatitis B vaccine R＆D and the immunization programmes in different countries, to summarizes the R＆D of both prophylactic and therapeutic vaccines,and points out the direction for futare vaccine development.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2006年第7期774-777,共4页
Academic Journal of Second Military Medical University
基金
中国科学院决策工程(SDP)项目(2005)2-3号~~
关键词
免疫计划
肝炎
乙型
疫苗
immunization programme
hepatitis B
vaccines
