摘要
经皮免疫是一种将抗原和佐剂局部应用于皮肤诱导产生全身免疫反应的一种新方法。皮肤不但是组织外源性物质包括病原体进入体内的物理屏障,还是复杂有效的免疫系统,因此皮肤是重要的免疫接种靶标。在人类和多种动物的实验中,经皮免疫的效果已经得到了证实。经皮免疫是一种免疫的新策略,有着广阔的实际应用前景。
Transcutaneous immunization (TCI), the topical application of antigen and adjuvant directly onto intact skin, which can safely and effectively elicit systemic and celluar immune responses in mice and humans against a variety of antigens, is a novel method of vaccine delivery. Not only the skin has evolved as a barrier to prevent external agents, including pathogens, from entering the body, but also it has a complex and efficient immune system, which includes Langer-hans' cells and dendritic cells. The skin is an attractive target for vaccine delivery. By targeting the body's natural defense system, TCI attempts to produce an efficient immune response. All these results highlight the likelihood that TCI will play an important role in vaccine applications in the future.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2006年第5期521-525,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30572269)
上海市卫生局科研课题基金资助项目(No054099)
关键词
经皮免疫
皮肤免疫系统
郎格汉斯细胞
疫苗
经皮给药系统
佐剂
transcutaneous immune (TCI)
skin immune system
transdermal drug Langerhans' cells ( LC )
vaccine
delivery system (TDDS)
adjuvant