免疫新策略:经皮免疫

A new immune strategy:Transcutaneous immune

经皮免疫是一种将抗原和佐剂局部应用于皮肤诱导产生全身免疫反应的一种新方法。皮肤不但是组织外源性物质包括病原体进入体内的物理屏障,还是复杂有效的免疫系统,因此皮肤是重要的免疫接种靶标。在人类和多种动物的实验中,经皮免疫的效果已经得到了证实。经皮免疫是一种免疫的新策略,有着广阔的实际应用前景。

Transcutaneous immunization （TCI）, the topical application of antigen and adjuvant directly onto intact skin, which can safely and effectively elicit systemic and celluar immune responses in mice and humans against a variety of antigens, is a novel method of vaccine delivery. Not only the skin has evolved as a barrier to prevent external agents, including pathogens, from entering the body, but also it has a complex and efficient immune system, which includes Langer-hans＇ cells and dendritic cells. The skin is an attractive target for vaccine delivery. By targeting the body＇s natural defense system, TCI attempts to produce an efficient immune response. All these results highlight the likelihood that TCI will play an important role in vaccine applications in the future.