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血红素氧化酶功能和调节及其在肝病发生中的研究进展 被引量：1

The function,regulation and development of heme oxygenase-1 in the liver disease
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摘要 血红素氧化酶是血红素降解过程中的一种限速酶,有3种亚型:HO-1、HO-2和HO-3,其中HO-1的研究较多。而HO-1所降解的产物是CO、铁和胆红素,它们具有重要的抗过氧化特性而保护细胞的功能;同时,在细胞内调节HO-1基因表达的信号通路以及HO-1基因启动因子均可诱导HO-1基因的抗过氧化应激能力,这就为因过氧化应激或非应激性所致的HO-1相关肝病的发病和治疗提供了新的方法。 Heme oxygenase （HO） is the rate-limiting enzyme in the degradation of heme. Three HO isoorms have been identified： HO-1, HO-2 and HO-3. The substances of heme degradation, carbon monoxide （CO） ,biliverdin and free iron（ Fe^2＋ ）, have an important function in anti-oxidant and protecting cells. And the anti-oxidant function of induction HO-1 expressionis mediated in the signal transduction of HO-1 gene expression and the promoter of HO-1 gene in the cells. So the new way is provided in the relevent liver-injury which is caused in anti-oxidant stress or non-oxidant stress.
作者 王晓红 曹琦 李俊 黄艳
机构地区 安徽医科大学药学院
出处 《中国药理学通报》 CAS CSCD 北大核心 2006年第5期525-528,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30470775)
关键词 血红素氧化酶 抗过氧化应激 信号通路 起动因子 Heme oxygenase, anti-oxidant, the signal transduction, promoter
分类号 R-05 [医药卫生] R329.2 [医药卫生—人体解剖和组织胚胎学]
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同被引文献13

  • 1叶放,薛博瑜,周珉,周仲瑛.论湿热瘀毒与肝纤维化[J].南京中医药大学学报,2005,21(6):346-349. 被引量：36
  • 2张斌,王灵台.中医药抗肝纤维化的实验研究进展[J].中西医结合学报,2006,4(2):206-210. 被引量：5
  • 3黄秀芳,陈必成,胡正杨,林丽娜,罗爱林.血红素加氧酶-1诱导对鼠肝缺血再灌注损伤的保护作用[J].肝胆胰外科杂志,2006,18(2):95-96. 被引量：2
  • 4Zhong Xi Yi Jie He Xue Bao Chinese Association of Integrative Medicine, Liver Disease Committee.肝纤维化中西医结合诊疗指南[J].中西医结合学报,2006,4(6):551-555. 被引量：28
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中国药理学通报
2006年 第5期

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