致病菌调控肠道上皮紧密连接的分子机制研究

The molecular regulating mechanisms of intestinal epithelial tight junctions response to pathogenic bacteria

肠道上皮紧密连接(TJ)是构成肠道屏障功能的重要结构基础,在调节肠黏膜通透性和维持上皮细胞极性中发挥着重要作用。目前,对TJ结构蛋白的研究已取得一定进展,但在病理状态下,TJ相关的调控机制仍未阐明。该文作者就常见肠道致病菌对TJ蛋白的分子调控机制及其他影响因素作一综述,旨在为完善肠屏障概念提供帮助。

Tight junctions（TJ） are the basic structure of intestinal barrier, which serve as the rate-limitting barrier to passive movement across intestinal epithelial cell and the maintenance of epithelial cell polarity. Recently some progress has been achieved in the structure of TJ proteins. This review is about the regulating mechanisms of TJs response to common enteric pathogens and other factors.