外科重症疾病获得性生长激素抵抗的研究进展

Progress of the mechanism of acquired growth hormone resistance in surgical critical illness

危重症疾病获得性生长激素抵抗,表现为血清生长激素浓度升高,胰岛素样生长因子-Ⅰ浓度减低,以及对外源性生长激素的促合成作用减弱。危重症病人外源性生长激素的使用可增加病死率。因此,深入理解获得性生长激素抵抗的机制具有理论意义和临床价值。该文作者对获得性生长激素抵抗的机制及其防治作如下综述。

Acquired growth hormone resistance（AGHR） in critical illness may be defined as the combination of a raised serum growth hormone concentration, low serum insulin-like growth factor-1 concentration and a reduced anabolic response to exogenous GH. GH given to reverse catabolism in critical illness increased mortality. Therefore, it has the theoretical significance and clinical value for better understanding of the mechanism of AGHR. The mechanism of AGHR and its prevention and cure are reviewed.