胃癌患者红细胞C3b受体与淋巴细胞免疫功能的相关性研究

Correlation study on the C3b receptor of red blood cells and function of lymphocyte function in gastric carcinoma patients

目的:研究胃癌患者红细胞C3b受体(RBC-C3bR)与淋巴细胞免疫功之间的关系。方法:利用酵母菌花环试验、MTT法及克隆抗体致敏花环法对51例胃癌患者及30例正常人的RBC-C3bR、自然杀伤细胞(NK)活性及T淋巴细胞(TC)亚群进行测定。结果:胃癌患者RBC-C3bR阳性率、NK细胞杀伤活性、CD3+、CD4+、CD4+/CD8+比值均比正常对照组显著低下(P<0·05,P<0·01)。经统计学相关性分析显示,RBC-C3bR阳性率与CD4+/CD8+比值、NK细胞杀伤活性间呈正相关(P<0·05,P<0·01)。结论:胃癌患者红细胞免疫功能与淋巴细胞免疫功能一样受到抑制,二者免疫功能密切联系、相互影响。

Objective：To evaluate the correlation of red blood cells and T lymphocyte（TC） immune function in gastric carcinoma patients. Methods：The red blood C3b receptor（RBC-C3bR） rosette, natural killer（NK） cell activity and T lymphocyte subsets of 51 cases of gastric carcinoma and 30 cases of normal subjects were measured by microzyme garland test, MTT-assay and monoclonal anti-human T lymphocyte antibody. Results： Compared with the control group, RBC-C3bR, NK cell activity, CD3 ^＋, CD4 ^＋, ratio of CD4^＋/CD8 ^＋ were significantly lower in gastric carcinoma group（ P 〈 0. 05, P 〈 0. 01 ） ; A positive correlation was observed between RBC-C3bR and NK cell activity, ratio of CD4 ^＋/CD8 ^＋（ P 〈 0. 05, P 〈 0. 01 ）. Conclusion：There was a close relationship between erythrocyte immune function and T lymphocyte subsets, NK cell activity.