中西医结合疗法改善肺癌患者厌食和体重减轻

Improvement of Anorexia and Weight Reducing in Patients with Lung Cancer by Integrated Chinese and Western Medicine

目的：观察比较“自拟启膈开胃汤”联合醋酸甲地孕酮分散片（宜利治）和单独使用宜利治对改善晚期肺癌患者厌食和体重减轻的疗效。方法：晚期肺癌患者64例，随机分成“自拟启膈开胃汤’’联合宜利治治疗（治疗组）和单独使用宜利治治疗（对照组）。观察两组对晚期肺癌患者厌食的改善和体重的影响及两组不良反应。结果：两组改善晚期肺癌患者厌食和体重减轻疗效相似（P＞0．05），但在副作用方面，治疗组心衰、浮肿、高血压、高血糖、便秘的发生率明显低于对照组（P＜0．05～0．01），肝功能损害和血栓性脉管炎发生情况两组无明显差别。结论：“自拟启膈开胃汤”联合宜利治治疗改善肺癌患者厌食和体重减轻确有增效解毒功效。

Objective：To observe the clinical, effect of Qigekaiwei decoction produced by author integrated with megestrol acetate and megestrol acetate only in improving of anorexia and weight reducing in patients with lung cancer. Methods：64 cases with lung cancer were randomly divided into the treatment group and the contrast group. The treatment group was treated bv Qigekaiwei decoction integrated with megestrol acetate and the contrast group by megestrol acetate only. The improvement of anorexia and weight reducing and side effects in both groups were observed and compared. Results：The improvement of anorexia and weight reducing in both groups were similar. While the side effect including heart failure, edema, blood pressure, blood sugar and constipation in the treatment group was obviously less than that in the contrast group. No significant difference was found in control of losing liver function and vascular inflammation in both groups. Conclusion ： Qigekaiwei decoction integrated with megestrol acetate can increase the detoxification function in improving of anorexia and weight reducing in patients with lung cancer.