来源于一种蛹拟青霉的抗肿瘤活性组分的分离纯化

Isolation and purification of antitumor compounds from fermentation broth of Paecilomyces militaris

在实验室大规模主要虫生真菌药物模型筛选的基础上,对安徽农业大学虫生真菌实验室保存的菌株蛹拟青霉[Paecilomyces m ilitaris(Kob.)B rown&Sm ith ex L iang]RCEF0718的抗肿瘤活性进行了进一步的研究。通过硅胶柱及凝胶柱的多步分离纯化,得到的化合物对多种肿瘤细胞具备良好的抑制活性。

Based on the screening of entomogenous deuteromycetes for pharmaceutical use, antitumor activity, extraction, purification and structure identification of RCEF0718 from Cordyceps mititaris were conducted, and several compounds （ 〉 95 % ） was isolated and purified for further research.